3SCZ
Combining crystallographic, thermodynamic, and molecular dynamics studies of Mycobacterium tuberculosis purine nucleoside phosphorylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006154 | biological_process | adenosine catabolic process |
| A | 0006161 | biological_process | deoxyguanosine catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006154 | biological_process | adenosine catabolic process |
| B | 0006161 | biological_process | deoxyguanosine catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HPA A 269 |
| Chain | Residue |
| A | ALA121 |
| A | HOH363 |
| A | GLY122 |
| A | GLU189 |
| A | GLY206 |
| A | MET207 |
| A | THR230 |
| A | ASN231 |
| A | LEU241 |
| A | HOH309 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE HPA B 269 |
| Chain | Residue |
| B | ALA120 |
| B | ALA121 |
| B | GLY122 |
| B | GLU189 |
| B | VAL205 |
| B | GLY206 |
| B | MET207 |
| B | THR230 |
| B | ASN231 |
| B | HOH316 |
| B | HOH340 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 42 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LvlaGriHaYeghdLryvVhpVrAaraaGaqi.MVltNAaGGL |
| Chain | Residue | Details |
| A | LEU83-LEU124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11444966, ECO:0007744|PDB:1G2O, ECO:0007744|PDB:1I80 |
| Chain | Residue | Details |
| A | SER36 | |
| A | ARG88 | |
| A | SER208 | |
| B | SER36 | |
| B | ARG88 | |
| B | SER208 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P45563 |
| Chain | Residue | Details |
| A | HIS68 | |
| A | ALA120 | |
| B | HIS68 | |
| B | ALA120 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11444966 |
| Chain | Residue | Details |
| A | GLU189 | |
| A | ASN231 | |
| B | GLU189 | |
| B | ASN231 |
