Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3SCF

Fe(II)-HppE with S-HPP and NO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008198	molecular_function	ferrous iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0016717	molecular_function	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
A	0017000	biological_process	antibiotic biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051289	biological_process	protein homotetramerization
A	0055114	biological_process	obsolete oxidation-reduction process
A	1901766	biological_process	phosphinothricin biosynthetic process
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008198	molecular_function	ferrous iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0016717	molecular_function	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
B	0017000	biological_process	antibiotic biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0051289	biological_process	protein homotetramerization
B	0055114	biological_process	obsolete oxidation-reduction process
B	1901766	biological_process	phosphinothricin biosynthetic process
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008198	molecular_function	ferrous iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0016717	molecular_function	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
C	0017000	biological_process	antibiotic biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0051289	biological_process	protein homotetramerization
C	0055114	biological_process	obsolete oxidation-reduction process
C	1901766	biological_process	phosphinothricin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 201

Chain	Residue
A	HIS138
A	GLU142
A	HIS180
A	S0H205
A	NO209

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 B 202

Chain	Residue
B	NO210
B	HIS138
B	GLU142
B	HIS180
B	S0H206

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 C 203

Chain	Residue
C	HIS138
C	GLU142
C	HIS180
C	S0H207
C	HOH214

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO A 209

Chain	Residue
A	HIS138
A	GLU142
A	ASN197
A	FE2201
A	S0H205

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO B 210

Chain	Residue
B	HIS138
B	GLU142
B	ASN197
B	FE2202
B	S0H206

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE S0H A 205

Chain	Residue
A	TYR103
A	TYR105
A	ASN135
A	HIS138
A	GLU142
A	HIS180
A	FE2201
A	NO209
B	LYS23

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE S0H B 206

Chain	Residue
A	LYS23
B	ARG97
B	TYR103
B	TYR105
B	ASN135
B	HIS138
B	GLU142
B	HIS180
B	PHE182
B	FE2202
B	HOH209
B	NO210

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE S0H C 207

Chain	Residue
C	LYS23
C	ARG97
C	TYR105
C	ASN135
C	HIS138
C	GLU142
C	HIS180
C	FE2203
C	HOH214

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 199

Chain	Residue
A	ARG90
A	LYS192
B	GLU148
B	GLY149
B	THR168

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 199

Chain	Residue
C	ARG90
C	GLU148
C	LYS192

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	165
Details	Domain: {"description":"HTH cro/C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	180
Details	Domain: {"description":"Cupin type-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	57
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00257","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16015285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16186494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21682308","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ZZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J1W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)