3SAH
Crystal structure of the human RRP6 catalytic domain with Y436A mutation in the catalytic site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000467 | biological_process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| B | 0000467 | biological_process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE YT3 A 1 |
| Chain | Residue |
| A | ASP295 |
| A | GLU296 |
| A | GLU299 |
| A | ASP488 |
| A | GLU489 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE YT3 A 3 |
| Chain | Residue |
| A | GLU315 |
| A | ASP440 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1 |
| Chain | Residue |
| B | ASP313 |
| B | LEU314 |
| B | ASP371 |
| B | HOH67 |
| B | HOH160 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 2 |
| Chain | Residue |
| B | HOH12 |
| B | GLU315 |
| B | ASP440 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE YT3 B 607 |
| Chain | Residue |
| B | HOH7 |
| B | HOH52 |
| B | GLU296 |
| B | GLU299 |
| B | ASP488 |
| B | GLU489 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Domain: {"description":"HRDC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00328","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21705430","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SAH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21705430","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SAH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Not ubiquitinated","evidences":[{"source":"PubMed","id":"36912080","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"36912080","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 166 |
| Details | Domain: {"description":"3'-5' exonuclease","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
