Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3S8E

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002218	biological_process	activation of innate immune response
A	0004175	molecular_function	endopeptidase activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016540	biological_process	protein autoprocessing
A	0030855	biological_process	epithelial cell differentiation
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043067	biological_process	regulation of programmed cell death
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0060545	biological_process	positive regulation of necroptotic process
A	0070269	biological_process	pyroptosis
A	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
A	0072734	biological_process	cellular response to staurosporine
A	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
A	0097194	biological_process	execution phase of apoptosis
A	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
A	0097284	biological_process	hepatocyte apoptotic process
B	0002218	biological_process	activation of innate immune response
B	0004175	molecular_function	endopeptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0008234	molecular_function	cysteine-type peptidase activity
B	0016540	biological_process	protein autoprocessing
B	0030855	biological_process	epithelial cell differentiation
B	0042802	molecular_function	identical protein binding
B	0043065	biological_process	positive regulation of apoptotic process
B	0043067	biological_process	regulation of programmed cell death
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0060545	biological_process	positive regulation of necroptotic process
B	0070269	biological_process	pyroptosis
B	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
B	0072734	biological_process	cellular response to staurosporine
B	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
B	0097194	biological_process	execution phase of apoptosis
B	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
B	0097284	biological_process	hepatocyte apoptotic process
C	0002218	biological_process	activation of innate immune response
C	0004175	molecular_function	endopeptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0008234	molecular_function	cysteine-type peptidase activity
C	0016540	biological_process	protein autoprocessing
C	0030855	biological_process	epithelial cell differentiation
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043067	biological_process	regulation of programmed cell death
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0060545	biological_process	positive regulation of necroptotic process
C	0070269	biological_process	pyroptosis
C	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
C	0072734	biological_process	cellular response to staurosporine
C	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
C	0097194	biological_process	execution phase of apoptosis
C	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
C	0097284	biological_process	hepatocyte apoptotic process
D	0002218	biological_process	activation of innate immune response
D	0004175	molecular_function	endopeptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0008234	molecular_function	cysteine-type peptidase activity
D	0016540	biological_process	protein autoprocessing
D	0030855	biological_process	epithelial cell differentiation
D	0042802	molecular_function	identical protein binding
D	0043065	biological_process	positive regulation of apoptotic process
D	0043067	biological_process	regulation of programmed cell death
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0060545	biological_process	positive regulation of necroptotic process
D	0070269	biological_process	pyroptosis
D	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
D	0072734	biological_process	cellular response to staurosporine
D	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
D	0097194	biological_process	execution phase of apoptosis
D	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
D	0097284	biological_process	hepatocyte apoptotic process
E	0002218	biological_process	activation of innate immune response
E	0004175	molecular_function	endopeptidase activity
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0008234	molecular_function	cysteine-type peptidase activity
E	0016540	biological_process	protein autoprocessing
E	0030855	biological_process	epithelial cell differentiation
E	0042802	molecular_function	identical protein binding
E	0043065	biological_process	positive regulation of apoptotic process
E	0043067	biological_process	regulation of programmed cell death
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0060545	biological_process	positive regulation of necroptotic process
E	0070269	biological_process	pyroptosis
E	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
E	0072734	biological_process	cellular response to staurosporine
E	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
E	0097194	biological_process	execution phase of apoptosis
E	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
E	0097284	biological_process	hepatocyte apoptotic process
F	0002218	biological_process	activation of innate immune response
F	0004175	molecular_function	endopeptidase activity
F	0004197	molecular_function	cysteine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0006915	biological_process	apoptotic process
F	0008234	molecular_function	cysteine-type peptidase activity
F	0016540	biological_process	protein autoprocessing
F	0030855	biological_process	epithelial cell differentiation
F	0042802	molecular_function	identical protein binding
F	0043065	biological_process	positive regulation of apoptotic process
F	0043067	biological_process	regulation of programmed cell death
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0060545	biological_process	positive regulation of necroptotic process
F	0070269	biological_process	pyroptosis
F	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
F	0072734	biological_process	cellular response to staurosporine
F	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
F	0097194	biological_process	execution phase of apoptosis
F	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
F	0097284	biological_process	hepatocyte apoptotic process
G	0002218	biological_process	activation of innate immune response
G	0004175	molecular_function	endopeptidase activity
G	0004197	molecular_function	cysteine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0006915	biological_process	apoptotic process
G	0008234	molecular_function	cysteine-type peptidase activity
G	0016540	biological_process	protein autoprocessing
G	0030855	biological_process	epithelial cell differentiation
G	0042802	molecular_function	identical protein binding
G	0043065	biological_process	positive regulation of apoptotic process
G	0043067	biological_process	regulation of programmed cell death
G	0043525	biological_process	positive regulation of neuron apoptotic process
G	0060545	biological_process	positive regulation of necroptotic process
G	0070269	biological_process	pyroptosis
G	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
G	0072734	biological_process	cellular response to staurosporine
G	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
G	0097194	biological_process	execution phase of apoptosis
G	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
G	0097284	biological_process	hepatocyte apoptotic process
H	0002218	biological_process	activation of innate immune response
H	0004175	molecular_function	endopeptidase activity
H	0004197	molecular_function	cysteine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006508	biological_process	proteolysis
H	0006915	biological_process	apoptotic process
H	0008234	molecular_function	cysteine-type peptidase activity
H	0016540	biological_process	protein autoprocessing
H	0030855	biological_process	epithelial cell differentiation
H	0042802	molecular_function	identical protein binding
H	0043065	biological_process	positive regulation of apoptotic process
H	0043067	biological_process	regulation of programmed cell death
H	0043525	biological_process	positive regulation of neuron apoptotic process
H	0060545	biological_process	positive regulation of necroptotic process
H	0070269	biological_process	pyroptosis
H	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
H	0072734	biological_process	cellular response to staurosporine
H	0097153	molecular_function	cysteine-type endopeptidase activity involved in apoptotic process
H	0097194	biological_process	execution phase of apoptosis
H	0097200	molecular_function	cysteine-type endopeptidase activity involved in execution phase of apoptosis
H	0097284	biological_process	hepatocyte apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HadadCfvCvFLSHG

Chain	Residue	Details
A	HIS108-GLY122

site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKIFIIQACRG

Chain	Residue	Details
A	LYS154-GLY165

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:30420425

Chain	Residue	Details
A	HIS121
B	HIS121
C	HIS121
D	HIS121
E	HIS121
F	HIS121
G	HIS121
H	HIS121

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:16123779, ECO:0000269\|PubMed:19133298, ECO:0000269\|PubMed:19694615, ECO:0000269\|PubMed:20890311, ECO:0000269\|PubMed:28864531, ECO:0000269\|PubMed:30420425

Chain	Residue	Details
A	CYS163
B	CYS163
C	CYS163
D	CYS163
E	CYS163
F	CYS163
G	CYS163
H	CYS163

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O08738

Chain	Residue	Details
A	SER79
B	SER79
C	SER79
D	SER79
E	SER79
F	SER79
G	SER79
H	SER79

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine; by NUAK1 and AMPK => ECO:0000269\|PubMed:15273717, ECO:0000269\|PubMed:22483120, ECO:0000269\|PubMed:32029622

Chain	Residue	Details
A	ASP257
B	ASP257
C	ASP257
D	ASP257
E	ASP257
F	ASP257
G	ASP257
H	ASP257

site_id	SWS_FT_FI5
Number of Residues	16
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:27911442

Chain	Residue	Details
A	CYS264
A	CYS277
B	CYS264
B	CYS277
C	CYS264
C	CYS277
D	CYS264
D	CYS277
E	CYS264
E	CYS277
F	CYS264
F	CYS277
G	CYS264
G	CYS277
H	CYS264
H	CYS277

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)