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3S8E

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

Functional Information from GO Data
ChainGOidnamespacecontents
A0002218biological_processactivation of innate immune response
A0004175molecular_functionendopeptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0016540biological_processprotein autoprocessing
A0016787molecular_functionhydrolase activity
A0030855biological_processepithelial cell differentiation
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043067biological_processregulation of programmed cell death
A0043525biological_processpositive regulation of neuron apoptotic process
A0051604biological_processprotein maturation
A0060545biological_processpositive regulation of necroptotic process
A0070269biological_processpyroptotic inflammatory response
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0072734biological_processcellular response to staurosporine
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0097284biological_processhepatocyte apoptotic process
B0002218biological_processactivation of innate immune response
B0004175molecular_functionendopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0016540biological_processprotein autoprocessing
B0016787molecular_functionhydrolase activity
B0030855biological_processepithelial cell differentiation
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043067biological_processregulation of programmed cell death
B0043525biological_processpositive regulation of neuron apoptotic process
B0051604biological_processprotein maturation
B0060545biological_processpositive regulation of necroptotic process
B0070269biological_processpyroptotic inflammatory response
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0072734biological_processcellular response to staurosporine
B0090200biological_processpositive regulation of release of cytochrome c from mitochondria
B0097284biological_processhepatocyte apoptotic process
C0002218biological_processactivation of innate immune response
C0004175molecular_functionendopeptidase activity
C0004197molecular_functioncysteine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0008233molecular_functionpeptidase activity
C0008234molecular_functioncysteine-type peptidase activity
C0016540biological_processprotein autoprocessing
C0016787molecular_functionhydrolase activity
C0030855biological_processepithelial cell differentiation
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043067biological_processregulation of programmed cell death
C0043525biological_processpositive regulation of neuron apoptotic process
C0051604biological_processprotein maturation
C0060545biological_processpositive regulation of necroptotic process
C0070269biological_processpyroptotic inflammatory response
C0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
C0072734biological_processcellular response to staurosporine
C0090200biological_processpositive regulation of release of cytochrome c from mitochondria
C0097284biological_processhepatocyte apoptotic process
D0002218biological_processactivation of innate immune response
D0004175molecular_functionendopeptidase activity
D0004197molecular_functioncysteine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0006915biological_processapoptotic process
D0008233molecular_functionpeptidase activity
D0008234molecular_functioncysteine-type peptidase activity
D0016540biological_processprotein autoprocessing
D0016787molecular_functionhydrolase activity
D0030855biological_processepithelial cell differentiation
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043067biological_processregulation of programmed cell death
D0043525biological_processpositive regulation of neuron apoptotic process
D0051604biological_processprotein maturation
D0060545biological_processpositive regulation of necroptotic process
D0070269biological_processpyroptotic inflammatory response
D0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
D0072734biological_processcellular response to staurosporine
D0090200biological_processpositive regulation of release of cytochrome c from mitochondria
D0097284biological_processhepatocyte apoptotic process
E0002218biological_processactivation of innate immune response
E0004175molecular_functionendopeptidase activity
E0004197molecular_functioncysteine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006508biological_processproteolysis
E0006915biological_processapoptotic process
E0008233molecular_functionpeptidase activity
E0008234molecular_functioncysteine-type peptidase activity
E0016540biological_processprotein autoprocessing
E0016787molecular_functionhydrolase activity
E0030855biological_processepithelial cell differentiation
E0042802molecular_functionidentical protein binding
E0043065biological_processpositive regulation of apoptotic process
E0043067biological_processregulation of programmed cell death
E0043525biological_processpositive regulation of neuron apoptotic process
E0051604biological_processprotein maturation
E0060545biological_processpositive regulation of necroptotic process
E0070269biological_processpyroptotic inflammatory response
E0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
E0072734biological_processcellular response to staurosporine
E0090200biological_processpositive regulation of release of cytochrome c from mitochondria
E0097284biological_processhepatocyte apoptotic process
F0002218biological_processactivation of innate immune response
F0004175molecular_functionendopeptidase activity
F0004197molecular_functioncysteine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006508biological_processproteolysis
F0006915biological_processapoptotic process
F0008233molecular_functionpeptidase activity
F0008234molecular_functioncysteine-type peptidase activity
F0016540biological_processprotein autoprocessing
F0016787molecular_functionhydrolase activity
F0030855biological_processepithelial cell differentiation
F0042802molecular_functionidentical protein binding
F0043065biological_processpositive regulation of apoptotic process
F0043067biological_processregulation of programmed cell death
F0043525biological_processpositive regulation of neuron apoptotic process
F0051604biological_processprotein maturation
F0060545biological_processpositive regulation of necroptotic process
F0070269biological_processpyroptotic inflammatory response
F0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
F0072734biological_processcellular response to staurosporine
F0090200biological_processpositive regulation of release of cytochrome c from mitochondria
F0097284biological_processhepatocyte apoptotic process
G0002218biological_processactivation of innate immune response
G0004175molecular_functionendopeptidase activity
G0004197molecular_functioncysteine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006508biological_processproteolysis
G0006915biological_processapoptotic process
G0008233molecular_functionpeptidase activity
G0008234molecular_functioncysteine-type peptidase activity
G0016540biological_processprotein autoprocessing
G0016787molecular_functionhydrolase activity
G0030855biological_processepithelial cell differentiation
G0042802molecular_functionidentical protein binding
G0043065biological_processpositive regulation of apoptotic process
G0043067biological_processregulation of programmed cell death
G0043525biological_processpositive regulation of neuron apoptotic process
G0051604biological_processprotein maturation
G0060545biological_processpositive regulation of necroptotic process
G0070269biological_processpyroptotic inflammatory response
G0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
G0072734biological_processcellular response to staurosporine
G0090200biological_processpositive regulation of release of cytochrome c from mitochondria
G0097284biological_processhepatocyte apoptotic process
H0002218biological_processactivation of innate immune response
H0004175molecular_functionendopeptidase activity
H0004197molecular_functioncysteine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006508biological_processproteolysis
H0006915biological_processapoptotic process
H0008233molecular_functionpeptidase activity
H0008234molecular_functioncysteine-type peptidase activity
H0016540biological_processprotein autoprocessing
H0016787molecular_functionhydrolase activity
H0030855biological_processepithelial cell differentiation
H0042802molecular_functionidentical protein binding
H0043065biological_processpositive regulation of apoptotic process
H0043067biological_processregulation of programmed cell death
H0043525biological_processpositive regulation of neuron apoptotic process
H0051604biological_processprotein maturation
H0060545biological_processpositive regulation of necroptotic process
H0070269biological_processpyroptotic inflammatory response
H0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
H0072734biological_processcellular response to staurosporine
H0090200biological_processpositive regulation of release of cytochrome c from mitochondria
H0097284biological_processhepatocyte apoptotic process
Functional Information from PROSITE/UniProt
site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HadadCfvCvFLSHG
ChainResidueDetails
AHIS108-GLY122

site_idPS01122
Number of Residues12
DetailsCASPASE_CYS Caspase family cysteine active site. KPKIFIIQACRG
ChainResidueDetails
ALYS154-GLY165

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:30420425
ChainResidueDetails
AHIS121
BHIS121
CHIS121
DHIS121
EHIS121
FHIS121
GHIS121
HHIS121

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:16123779, ECO:0000269|PubMed:19133298, ECO:0000269|PubMed:19694615, ECO:0000269|PubMed:20890311, ECO:0000269|PubMed:28864531, ECO:0000269|PubMed:30420425
ChainResidueDetails
ACYS163
BCYS163
CCYS163
DCYS163
ECYS163
FCYS163
GCYS163
HCYS163

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08738
ChainResidueDetails
ASER79
BSER79
CSER79
DSER79
ESER79
FSER79
GSER79
HSER79

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphoserine; by NUAK1 and AMPK => ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:22483120, ECO:0000269|PubMed:32029622
ChainResidueDetails
AASP257
BASP257
CASP257
DASP257
EASP257
FASP257
GASP257
HASP257

site_idSWS_FT_FI5
Number of Residues16
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:27911442
ChainResidueDetails
ACYS264
ECYS277
FCYS264
FCYS277
GCYS264
GCYS277
HCYS264
HCYS277
ACYS277
BCYS264
BCYS277
CCYS264
CCYS277
DCYS264
DCYS277
ECYS264

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PDB entries from 2025-06-11

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