3S86
Crystal Structure of TM0159 with bound IMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| A | 0009146 | biological_process | purine nucleoside triphosphate catabolic process |
| A | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| A | 0035870 | molecular_function | dITP diphosphatase activity |
| A | 0036220 | molecular_function | ITP diphosphatase activity |
| A | 0036222 | molecular_function | XTP diphosphatase activity |
| A | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| B | 0009146 | biological_process | purine nucleoside triphosphate catabolic process |
| B | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| B | 0035870 | molecular_function | dITP diphosphatase activity |
| B | 0036220 | molecular_function | ITP diphosphatase activity |
| B | 0036222 | molecular_function | XTP diphosphatase activity |
| B | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| C | 0009146 | biological_process | purine nucleoside triphosphate catabolic process |
| C | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| C | 0035870 | molecular_function | dITP diphosphatase activity |
| C | 0036220 | molecular_function | ITP diphosphatase activity |
| C | 0036222 | molecular_function | XTP diphosphatase activity |
| C | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| D | 0009146 | biological_process | purine nucleoside triphosphate catabolic process |
| D | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| D | 0035870 | molecular_function | dITP diphosphatase activity |
| D | 0036220 | molecular_function | ITP diphosphatase activity |
| D | 0036222 | molecular_function | XTP diphosphatase activity |
| D | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE IMP A 197 |
| Chain | Residue |
| A | LYS15 |
| A | PHE113 |
| A | PHE148 |
| A | GLY149 |
| A | TYR150 |
| A | ASP151 |
| A | LYS170 |
| A | HIS175 |
| A | ARG176 |
| A | SO4198 |
| A | HOH237 |
| A | LYS52 |
| A | ASP67 |
| A | ASP68 |
| A | SER69 |
| A | GLY70 |
| A | SER84 |
| A | ALA85 |
| A | TYR93 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 198 |
| Chain | Residue |
| A | THR10 |
| A | THR11 |
| A | LYS15 |
| A | LYS52 |
| A | ASP67 |
| A | IMP197 |
| A | HOH221 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE IMP B 197 |
| Chain | Residue |
| B | LYS15 |
| B | GLU40 |
| B | ASP68 |
| B | SER69 |
| B | GLY70 |
| B | SER84 |
| B | ALA85 |
| B | TYR93 |
| B | PHE113 |
| B | PHE148 |
| B | GLY149 |
| B | TYR150 |
| B | ASP151 |
| B | LYS170 |
| B | HIS175 |
| B | ARG176 |
| B | SO4198 |
| B | HOH244 |
| B | HOH250 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 198 |
| Chain | Residue |
| B | THR10 |
| B | THR11 |
| B | ASN12 |
| B | LYS15 |
| B | GLU40 |
| B | LYS52 |
| B | ASP67 |
| B | IMP197 |
| B | HOH220 |
| B | HOH250 |
| B | HOH253 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE IMP C 197 |
| Chain | Residue |
| C | LYS15 |
| C | GLU40 |
| C | ASP68 |
| C | SER69 |
| C | GLY70 |
| C | SER84 |
| C | ALA85 |
| C | TYR93 |
| C | PHE113 |
| C | PHE148 |
| C | GLY149 |
| C | TYR150 |
| C | ASP151 |
| C | LYS170 |
| C | HIS175 |
| C | ARG176 |
| C | SO4198 |
| C | HOH203 |
| C | HOH224 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 198 |
| Chain | Residue |
| C | THR10 |
| C | THR11 |
| C | ASN12 |
| C | LYS15 |
| C | GLU40 |
| C | LYS52 |
| C | ASP67 |
| C | IMP197 |
| C | HOH224 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE IMP D 197 |
| Chain | Residue |
| D | HIS175 |
| D | ARG176 |
| D | SO4198 |
| D | HOH217 |
| D | HOH234 |
| D | LYS15 |
| D | GLU40 |
| D | LYS52 |
| D | ASP68 |
| D | SER69 |
| D | GLY70 |
| D | SER84 |
| D | ALA85 |
| D | TYR93 |
| D | PHE113 |
| D | PHE148 |
| D | GLY149 |
| D | TYR150 |
| D | ASP151 |
| D | LYS170 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 198 |
| Chain | Residue |
| D | THR10 |
| D | THR11 |
| D | LYS15 |
| D | GLU40 |
| D | LYS52 |
| D | ASP67 |
| D | IMP197 |
| D | HOH234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01405","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01405","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
