3S86

Crystal Structure of TM0159 with bound IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009117	biological_process	nucleotide metabolic process
A	0009143	biological_process	nucleoside triphosphate catabolic process
A	0009146	biological_process	purine nucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
A	0035870	molecular_function	dITP diphosphatase activity
A	0036220	molecular_function	ITP diphosphatase activity
A	0036222	molecular_function	XTP diphosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0000166	molecular_function	nucleotide binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009117	biological_process	nucleotide metabolic process
B	0009143	biological_process	nucleoside triphosphate catabolic process
B	0009146	biological_process	purine nucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
B	0035870	molecular_function	dITP diphosphatase activity
B	0036220	molecular_function	ITP diphosphatase activity
B	0036222	molecular_function	XTP diphosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
C	0000166	molecular_function	nucleotide binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009117	biological_process	nucleotide metabolic process
C	0009143	biological_process	nucleoside triphosphate catabolic process
C	0009146	biological_process	purine nucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
C	0035870	molecular_function	dITP diphosphatase activity
C	0036220	molecular_function	ITP diphosphatase activity
C	0036222	molecular_function	XTP diphosphatase activity
C	0046872	molecular_function	metal ion binding
C	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
D	0000166	molecular_function	nucleotide binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009117	biological_process	nucleotide metabolic process
D	0009143	biological_process	nucleoside triphosphate catabolic process
D	0009146	biological_process	purine nucleoside triphosphate catabolic process
D	0016787	molecular_function	hydrolase activity
D	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
D	0035870	molecular_function	dITP diphosphatase activity
D	0036220	molecular_function	ITP diphosphatase activity
D	0036222	molecular_function	XTP diphosphatase activity
D	0046872	molecular_function	metal ion binding
D	0047429	molecular_function	nucleoside triphosphate diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IMP A 197

Chain	Residue
A	LYS15
A	PHE113
A	PHE148
A	GLY149
A	TYR150
A	ASP151
A	LYS170
A	HIS175
A	ARG176
A	SO4198
A	HOH237
A	LYS52
A	ASP67
A	ASP68
A	SER69
A	GLY70
A	SER84
A	ALA85
A	TYR93

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 198

Chain	Residue
A	THR10
A	THR11
A	LYS15
A	LYS52
A	ASP67
A	IMP197
A	HOH221

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IMP B 197

Chain	Residue
B	LYS15
B	GLU40
B	ASP68
B	SER69
B	GLY70
B	SER84
B	ALA85
B	TYR93
B	PHE113
B	PHE148
B	GLY149
B	TYR150
B	ASP151
B	LYS170
B	HIS175
B	ARG176
B	SO4198
B	HOH244
B	HOH250

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 B 198

Chain	Residue
B	THR10
B	THR11
B	ASN12
B	LYS15
B	GLU40
B	LYS52
B	ASP67
B	IMP197
B	HOH220
B	HOH250
B	HOH253

---

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IMP C 197

Chain	Residue
C	LYS15
C	GLU40
C	ASP68
C	SER69
C	GLY70
C	SER84
C	ALA85
C	TYR93
C	PHE113
C	PHE148
C	GLY149
C	TYR150
C	ASP151
C	LYS170
C	HIS175
C	ARG176
C	SO4198
C	HOH203
C	HOH224

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 198

Chain	Residue
C	THR10
C	THR11
C	ASN12
C	LYS15
C	GLU40
C	LYS52
C	ASP67
C	IMP197
C	HOH224

---

site_id	AC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE IMP D 197

Chain	Residue
D	HIS175
D	ARG176
D	SO4198
D	HOH217
D	HOH234
D	LYS15
D	GLU40
D	LYS52
D	ASP68
D	SER69
D	GLY70
D	SER84
D	ALA85
D	TYR93
D	PHE113
D	PHE148
D	GLY149
D	TYR150
D	ASP151
D	LYS170

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 198

Chain	Residue
D	THR10
D	THR11
D	LYS15
D	GLU40
D	LYS52
D	ASP67
D	IMP197
D	HOH234

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01405

Chain	Residue	Details
A	ASP68
B	ASP68
C	ASP68
D	ASP68

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01405

Chain	Residue	Details
A	THR10
B	HIS175
C	THR10
C	ASP68
C	SER69
C	PHE148
C	HIS175
D	THR10
D	ASP68
D	SER69
D	PHE148
A	ASP68
D	HIS175
A	SER69
A	PHE148
A	HIS175
B	THR10
B	ASP68
B	SER69
B	PHE148

---