3S6T

Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 V327G complexed with PUGNAc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004563	molecular_function	beta-N-acetylhexosaminidase activity
A	0005975	biological_process	carbohydrate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OAN A 1

Chain	Residue
A	ARG220
A	GLU526
A	HOH885
A	HIS303
A	ASP367
A	TRP424
A	TRP448
A	TYR475
A	ASP477
A	TRP490
A	TRP524

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:21106526

Chain	Residue	Details
A	ASP249
A	HIS303
A	GLU368

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Important determinant of glycosidic bond specificity => ECO:0000269|PubMed:23300622

Chain	Residue	Details
A	GLY327

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Essential for chitooligosaccharide substrate binding => ECO:0000269|PubMed:23300622

Chain	Residue	Details
A	GLU328
A	TRP490

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:25155420, ECO:0000269|PubMed:30135205, ECO:0007744|PDB:3WMB, ECO:0007744|PDB:3WMC, ECO:0007744|PDB:5Y0V, ECO:0007744|PDB:5Y1B

Chain	Residue	Details
A	ASN164
A	ASN375

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