Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3S5L

Crystal structure of CD4 mutant bound to HLA-DR1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
A	0019882	biological_process	antigen processing and presentation
A	0042613	cellular_component	MHC class II protein complex
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
B	0019882	biological_process	antigen processing and presentation
B	0042613	cellular_component	MHC class II protein complex
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
D	0019882	biological_process	antigen processing and presentation
D	0042613	cellular_component	MHC class II protein complex
E	0006955	biological_process	immune response
E	0016020	cellular_component	membrane
E	0019882	biological_process	antigen processing and presentation
E	0042613	cellular_component	MHC class II protein complex
G	0007155	biological_process	cell adhesion
G	0016020	cellular_component	membrane
H	0007155	biological_process	cell adhesion
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 968

Chain	Residue
A	ARG44
A	ASN94
A	VAL104
A	TYR150
A	HOH244
B	ASP152

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 961

Chain	Residue
E	ASP152
D	ARG44
D	VAL104
D	TYR150

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 966

Chain	Residue
B	ILE127
B	GLU128
B	VAL129
B	SER144
B	GLY146
B	THR157

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 969

Chain	Residue
B	SER126
B	GLU128
B	GLU176
B	HIS177
B	PRO178
B	HOH267

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 960

Chain	Residue
E	SER126
E	ILE127
E	GLU128
E	GLU176
E	HIS177
E	PRO178

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 962

Chain	Residue
E	LEU114
E	GLU162
H	GLN25
H	LYS35
H	ASN39
H	TRP45

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL E 963

Chain	Residue
E	VAL129
E	SER144
E	GLY146
E	THR157

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL G 965

Chain	Residue
G	ARG58
G	ARG60

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL G 967

Chain	Residue
B	GLU162
G	LYS35
G	ASN39
G	TRP45

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL H 964

Chain	Residue
D	HOH220
H	ARG58
H	ARG60

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH

Chain	Residue	Details
A	TYR161-HIS167
B	TYR171-HIS177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	186
Details	Region: {"description":"Alpha-2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Self-peptide antigen","evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7477400","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	188
Details	Region: {"description":"Beta-1"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19303388","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24190431","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	99
Details	Domain: {"description":"Ig-like V-type"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)