3S5L
Crystal structure of CD4 mutant bound to HLA-DR1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0042613 | cellular_component | MHC class II protein complex |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0042613 | cellular_component | MHC class II protein complex |
| D | 0006955 | biological_process | immune response |
| D | 0016020 | cellular_component | membrane |
| D | 0019882 | biological_process | antigen processing and presentation |
| D | 0042613 | cellular_component | MHC class II protein complex |
| E | 0006955 | biological_process | immune response |
| E | 0016020 | cellular_component | membrane |
| E | 0019882 | biological_process | antigen processing and presentation |
| E | 0042613 | cellular_component | MHC class II protein complex |
| G | 0007155 | biological_process | cell adhesion |
| G | 0016020 | cellular_component | membrane |
| H | 0007155 | biological_process | cell adhesion |
| H | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 968 |
| Chain | Residue |
| A | ARG44 |
| A | ASN94 |
| A | VAL104 |
| A | TYR150 |
| A | HOH244 |
| B | ASP152 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 961 |
| Chain | Residue |
| E | ASP152 |
| D | ARG44 |
| D | VAL104 |
| D | TYR150 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 966 |
| Chain | Residue |
| B | ILE127 |
| B | GLU128 |
| B | VAL129 |
| B | SER144 |
| B | GLY146 |
| B | THR157 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 969 |
| Chain | Residue |
| B | SER126 |
| B | GLU128 |
| B | GLU176 |
| B | HIS177 |
| B | PRO178 |
| B | HOH267 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 960 |
| Chain | Residue |
| E | SER126 |
| E | ILE127 |
| E | GLU128 |
| E | GLU176 |
| E | HIS177 |
| E | PRO178 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 962 |
| Chain | Residue |
| E | LEU114 |
| E | GLU162 |
| H | GLN25 |
| H | LYS35 |
| H | ASN39 |
| H | TRP45 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL E 963 |
| Chain | Residue |
| E | VAL129 |
| E | SER144 |
| E | GLY146 |
| E | THR157 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL G 965 |
| Chain | Residue |
| G | ARG58 |
| G | ARG60 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL G 967 |
| Chain | Residue |
| B | GLU162 |
| G | LYS35 |
| G | ASN39 |
| G | TRP45 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL H 964 |
| Chain | Residue |
| D | HOH220 |
| H | ARG58 |
| H | ARG60 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH |
| Chain | Residue | Details |
| B | TYR171-HIS177 | |
| A | TYR161-HIS167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| B | ASP57 | |
| B | TRP61 | |
| B | HIS81 | |
| B | ASN82 | |
| E | ASP57 | |
| E | TRP61 | |
| E | HIS81 | |
| E | ASN82 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| B | ARG93 | |
| E | ARG93 | |
| D | GLY49 | |
| D | ALA52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 |
| Chain | Residue | Details |
| B | ASN19 | |
| E | ASN19 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| A | SER53 | |
| D | SER53 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | GLU55 | |
| D | GLU55 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN62 | |
| D | ASN62 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN69 | |
| D | ASN69 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ARG76 | |
| D | ARG76 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
| Chain | Residue | Details |
| A | ASN78 | |
| A | ASN118 | |
| D | ASN78 | |
| D | ASN118 |
