3S4O
Protein Tyrosine Phosphatase (putative) from Leishmania major
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0020023 | cellular_component | kinetoplast |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0020023 | cellular_component | kinetoplast |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE THJ A 170 |
| Chain | Residue |
| A | ASP74 |
| A | CYS112 |
| A | VAL113 |
| A | ALA114 |
| A | GLY115 |
| A | LEU116 |
| A | GLY117 |
| A | ARG118 |
| A | ALA119 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE EPE A 164 |
| Chain | Residue |
| A | HIS41 |
| A | ARG42 |
| A | GLY43 |
| A | ARG45 |
| A | ARG96 |
| A | PRO104 |
| A | PRO105 |
| A | PRO106 |
| A | THR107 |
| A | HOH190 |
| A | HOH193 |
| A | HOH202 |
| B | HIS41 |
| B | ARG42 |
| B | GLY43 |
| B | ARG45 |
| B | ARG96 |
| B | PRO105 |
| B | PRO106 |
| B | THR107 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"MAY-2011","submissionDatabase":"PDB data bank","title":"Protein tyrosine phosphatase from Leishmania major.","authors":["Merritt E.A.","Arakaki T.","Neely H.","Phizicky E.","Quartley E.","Van Voorhis W.C.","Buckner F.S.","Fan E.","Zucker F.","Verlinde C.L.M.J.","Hol W.G.J."]}}]} |
| Chain | Residue | Details |
