3RZU

The Crystal Structure of the Catalytic Domain of AMSH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016579	biological_process	protein deubiquitination
A	0061578	molecular_function	K63-linked deubiquitinase activity
A	0070536	biological_process	protein K63-linked deubiquitination
A	0140492	molecular_function	metal-dependent deubiquitinase activity
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0016579	biological_process	protein deubiquitination
B	0061578	molecular_function	K63-linked deubiquitinase activity
B	0070536	biological_process	protein K63-linked deubiquitination
B	0140492	molecular_function	metal-dependent deubiquitinase activity
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0016579	biological_process	protein deubiquitination
C	0061578	molecular_function	K63-linked deubiquitinase activity
C	0070536	biological_process	protein K63-linked deubiquitination
C	0140492	molecular_function	metal-dependent deubiquitinase activity
D	0008233	molecular_function	peptidase activity
D	0008237	molecular_function	metallopeptidase activity
D	0016579	biological_process	protein deubiquitination
D	0061578	molecular_function	K63-linked deubiquitinase activity
D	0070536	biological_process	protein K63-linked deubiquitination
D	0140492	molecular_function	metal-dependent deubiquitinase activity
E	0008233	molecular_function	peptidase activity
E	0008237	molecular_function	metallopeptidase activity
E	0016579	biological_process	protein deubiquitination
E	0061578	molecular_function	K63-linked deubiquitinase activity
E	0070536	biological_process	protein K63-linked deubiquitination
E	0140492	molecular_function	metal-dependent deubiquitinase activity
F	0008233	molecular_function	peptidase activity
F	0008237	molecular_function	metallopeptidase activity
F	0016579	biological_process	protein deubiquitination
F	0061578	molecular_function	K63-linked deubiquitinase activity
F	0070536	biological_process	protein K63-linked deubiquitination
F	0140492	molecular_function	metal-dependent deubiquitinase activity
G	0008233	molecular_function	peptidase activity
G	0008237	molecular_function	metallopeptidase activity
G	0016579	biological_process	protein deubiquitination
G	0061578	molecular_function	K63-linked deubiquitinase activity
G	0070536	biological_process	protein K63-linked deubiquitination
G	0140492	molecular_function	metal-dependent deubiquitinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HOH14
A	HIS335
A	HIS337
A	ASP348

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	HIS350
A	CYS390
A	HIS396
A	HIS398

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 3

Chain	Residue
B	HIS337
B	ASP348
B	HIS335

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 4

Chain	Residue
B	HIS350
B	CYS390
B	HIS396
B	HIS398

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 5

Chain	Residue
C	HOH134
C	HIS335
C	HIS337
C	ASP348

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 6

Chain	Residue
C	HIS350
C	CYS390
C	HIS396
C	HIS398

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 7

Chain	Residue
D	HIS335
D	HIS337
D	ASP348

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 8

Chain	Residue
D	HOH136
D	HIS350
D	CYS390
D	HIS396
D	HIS398

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 9

Chain	Residue
E	HOH135
E	HIS335
E	HIS337
E	ASP348

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 10

Chain	Residue
E	HOH103
E	HIS350
E	CYS390
E	HIS396
E	HIS398

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 11

Chain	Residue
F	HOH155
F	HIS335
F	HIS337
F	ASP348

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 12

Chain	Residue
F	HIS350
F	CYS390
F	HIS396
F	HIS398

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 13

Chain	Residue
G	HOH138
G	HIS335
G	HIS337
G	ASP348

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 14

Chain	Residue
G	HOH79
G	HIS350
G	CYS390
G	HIS396
G	HIS398

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	917
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	91
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96FJ0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Site: {"description":"Indirect zinc-binding","evidences":[{"source":"UniProtKB","id":"Q96FJ0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---