3RZU
The Crystal Structure of the Catalytic Domain of AMSH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| A | 0070536 | biological_process | protein K63-linked deubiquitination |
| A | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016579 | biological_process | protein deubiquitination |
| B | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| B | 0070536 | biological_process | protein K63-linked deubiquitination |
| B | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0016579 | biological_process | protein deubiquitination |
| C | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| C | 0070536 | biological_process | protein K63-linked deubiquitination |
| C | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0016579 | biological_process | protein deubiquitination |
| D | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| D | 0070536 | biological_process | protein K63-linked deubiquitination |
| D | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0008237 | molecular_function | metallopeptidase activity |
| E | 0016579 | biological_process | protein deubiquitination |
| E | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| E | 0070536 | biological_process | protein K63-linked deubiquitination |
| E | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0008237 | molecular_function | metallopeptidase activity |
| F | 0016579 | biological_process | protein deubiquitination |
| F | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| F | 0070536 | biological_process | protein K63-linked deubiquitination |
| F | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0008237 | molecular_function | metallopeptidase activity |
| G | 0016579 | biological_process | protein deubiquitination |
| G | 0061578 | molecular_function | K63-linked deubiquitinase activity |
| G | 0070536 | biological_process | protein K63-linked deubiquitination |
| G | 0140492 | molecular_function | metal-dependent deubiquitinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | HOH14 |
| A | HIS335 |
| A | HIS337 |
| A | ASP348 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2 |
| Chain | Residue |
| A | HIS350 |
| A | CYS390 |
| A | HIS396 |
| A | HIS398 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 3 |
| Chain | Residue |
| B | HIS337 |
| B | ASP348 |
| B | HIS335 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 4 |
| Chain | Residue |
| B | HIS350 |
| B | CYS390 |
| B | HIS396 |
| B | HIS398 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 5 |
| Chain | Residue |
| C | HOH134 |
| C | HIS335 |
| C | HIS337 |
| C | ASP348 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 6 |
| Chain | Residue |
| C | HIS350 |
| C | CYS390 |
| C | HIS396 |
| C | HIS398 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN D 7 |
| Chain | Residue |
| D | HIS335 |
| D | HIS337 |
| D | ASP348 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 8 |
| Chain | Residue |
| D | HOH136 |
| D | HIS350 |
| D | CYS390 |
| D | HIS396 |
| D | HIS398 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 9 |
| Chain | Residue |
| E | HOH135 |
| E | HIS335 |
| E | HIS337 |
| E | ASP348 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN E 10 |
| Chain | Residue |
| E | HOH103 |
| E | HIS350 |
| E | CYS390 |
| E | HIS396 |
| E | HIS398 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 11 |
| Chain | Residue |
| F | HOH155 |
| F | HIS335 |
| F | HIS337 |
| F | ASP348 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 12 |
| Chain | Residue |
| F | HIS350 |
| F | CYS390 |
| F | HIS396 |
| F | HIS398 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN G 13 |
| Chain | Residue |
| G | HOH138 |
| G | HIS335 |
| G | HIS337 |
| G | ASP348 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN G 14 |
| Chain | Residue |
| G | HOH79 |
| G | HIS350 |
| G | CYS390 |
| G | HIS396 |
| G | HIS398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 |
| Chain | Residue | Details |
| A | HIS335 | |
| D | HIS335 | |
| D | HIS337 | |
| D | ASP348 | |
| E | HIS335 | |
| E | HIS337 | |
| E | ASP348 | |
| F | HIS335 | |
| F | HIS337 | |
| F | ASP348 | |
| G | HIS335 | |
| A | HIS337 | |
| G | HIS337 | |
| G | ASP348 | |
| A | ASP348 | |
| B | HIS335 | |
| B | HIS337 | |
| B | ASP348 | |
| C | HIS335 | |
| C | HIS337 | |
| C | ASP348 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q96FJ0 |
| Chain | Residue | Details |
| A | HIS350 | |
| C | CYS390 | |
| C | HIS396 | |
| C | HIS398 | |
| D | HIS350 | |
| D | CYS390 | |
| D | HIS396 | |
| D | HIS398 | |
| E | HIS350 | |
| E | CYS390 | |
| E | HIS396 | |
| A | CYS390 | |
| E | HIS398 | |
| F | HIS350 | |
| F | CYS390 | |
| F | HIS396 | |
| F | HIS398 | |
| G | HIS350 | |
| G | CYS390 | |
| G | HIS396 | |
| G | HIS398 | |
| A | HIS396 | |
| A | HIS398 | |
| B | HIS350 | |
| B | CYS390 | |
| B | HIS396 | |
| B | HIS398 | |
| C | HIS350 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | SITE: Indirect zinc-binding => ECO:0000250|UniProtKB:Q96FJ0 |
| Chain | Residue | Details |
| A | GLU280 | |
| B | GLU280 | |
| C | GLU280 | |
| D | GLU280 | |
| E | GLU280 | |
| F | GLU280 | |
| G | GLU280 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:11483516, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER243 | |
| E | SER247 | |
| F | SER243 | |
| F | SER247 | |
| G | SER243 | |
| G | SER247 | |
| A | SER247 | |
| B | SER243 | |
| B | SER247 | |
| C | SER243 | |
| C | SER247 | |
| D | SER243 | |
| D | SER247 | |
| E | SER243 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:11483516 |
| Chain | Residue | Details |
| A | SER245 | |
| B | SER245 | |
| C | SER245 | |
| D | SER245 | |
| E | SER245 | |
| F | SER245 | |
| G | SER245 |
