3RZ2
Crystal of Prl-1 complexed with peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005769 | cellular_component | early endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005819 | cellular_component | spindle |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030335 | biological_process | positive regulation of cell migration |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005769 | cellular_component | early endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005819 | cellular_component | spindle |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030335 | biological_process | positive regulation of cell migration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR CHAIN C OF PRL-1 (PTP4A1) |
| Chain | Residue |
| A | ARG47 |
| A | ASP67 |
| A | TRP68 |
| A | LYS89 |
| A | ILE90 |
| A | ARG93 |
| A | ARG153 |
| A | ARG157 |
| A | ARG159 |
| B | SER86 |
| B | ARG157 |
| A | TYR53 |
| B | ARG159 |
| A | ASP54 |
| A | THR55 |
| A | THR56 |
| A | GLU59 |
| A | HIS64 |
| A | VAL65 |
| A | LEU66 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR CHAIN D OF PRL-1 (PTP4A1) |
| Chain | Residue |
| B | ASP54 |
| B | THR55 |
| B | THR56 |
| B | TRP68 |
| B | ASP83 |
| D | HOH20 |
| D | HOH36 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Region: {"description":"Interaction with ATF5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
