3RVB

The structure of HCV NS3 helicase (Heli-80) bound with inhibitor ITMN-3479

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE I79 A 1

Chain	Residue
A	HOH68
A	THR298
A	ALA497
A	TRP501
A	TYR502
A	HOH98
A	VAL232
A	GLY255
A	THR269
A	GLY271
A	LYS272
A	ALA275
A	SER297

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	HOH38
A	HOH38
A	ASN387
A	ASN387
A	ALA388

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 3

Chain	Residue
A	HOH36
A	HOH77
A	GLY209
A	LYS210
A	SER211
A	THR212

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 4

Chain	Residue
A	PHE536

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	ALA204

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9WMX2

Chain	Residue	Details
A	SER211
A	GLU291

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by serine protease/helicase NS3 => ECO:0000250|UniProtKB:P27958

Chain	Residue	Details
A	THR631

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