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3RUU

FXR with SRC1 and GSK237

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 473
ChainResidue
AASN271
ALYS275
ASER279
AALA280
AASN354

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
ALYS338
AGLN379

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 37G A 1
ChainResidue
ALEU287
ATHR288
AALA291
AHIS294
AMET328
APHE329
AARG331
ASER342
ATYR369
AHIS447
ATRP454
AMET265
ATHR270

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0007744|PDB:6HL1
ChainResidueDetails
AARG331
ATYR361
ATYR369
AHIS447

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687
ChainResidueDetails
ATHR442

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875
ChainResidueDetails
ALYS275

226707

PDB entries from 2024-10-30

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