3RUF

Alternative analogs as viable substrates of UDP-hexose 4-epimerases

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003974	molecular_function	UDP-N-acetylglucosamine 4-epimerase activity
A	0009243	biological_process	O antigen biosynthetic process
A	0016853	molecular_function	isomerase activity
B	0000166	molecular_function	nucleotide binding
B	0003974	molecular_function	UDP-N-acetylglucosamine 4-epimerase activity
B	0009243	biological_process	O antigen biosynthetic process
B	0016853	molecular_function	isomerase activity
S	0000166	molecular_function	nucleotide binding
S	0003974	molecular_function	UDP-N-acetylglucosamine 4-epimerase activity
S	0009243	biological_process	O antigen biosynthetic process
S	0016853	molecular_function	isomerase activity
b	0000166	molecular_function	nucleotide binding
b	0003974	molecular_function	UDP-N-acetylglucosamine 4-epimerase activity
b	0009243	biological_process	O antigen biosynthetic process
b	0016853	molecular_function	isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAD A 343

Chain	Residue
A	GLY23
A	THR51
A	GLY52
A	GLY77
A	ASP78
A	ILE79
A	GLN98
A	ALA99
A	ALA100
A	THR117
A	ALA140
A	ALA25
A	ALA141
A	TYR166
A	LYS170
A	TYR193
A	VAL196
A	HOH346
A	HOH348
A	HOH380
A	HOH386
A	HOH421
A	GLY26
A	HOH462
A	HOH606
A	PHE27
A	ILE28
A	ASP47
A	ASN48
A	PHE49
A	SER50

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE UDP A 344

Chain	Residue
A	ASN195
A	ALA209
A	VAL210
A	LYS213
A	TRP214
A	TYR225
A	ILE226
A	ASN227
A	THR232
A	ARG234
A	LEU271
A	ARG299
A	ASP302
A	HOH359
A	HOH425
A	HOH1023

---

site_id	AC3
Number of Residues	34
Details	BINDING SITE FOR RESIDUE NAD B 343

Chain	Residue
B	GLY23
B	ALA25
B	GLY26
B	PHE27
B	ILE28
B	ASP47
B	ASN48
B	PHE49
B	SER50
B	THR51
B	GLY52
B	GLY77
B	ASP78
B	ILE79
B	GLN98
B	ALA99
B	ALA100
B	THR117
B	ALA140
B	ALA141
B	TYR166
B	LYS170
B	TYR193
B	ASN195
B	VAL196
B	HOH346
B	HOH348
B	HOH368
B	HOH377
B	HOH390
B	HOH392
B	HOH404
B	HOH407
B	HOH578

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE UDP B 344

Chain	Residue
B	ASN195
B	ALA209
B	VAL210
B	LYS213
B	TYR225
B	ILE226
B	ASN227
B	THR232
B	ARG234
B	LEU271
B	ARG299
B	ASP302
B	HOH372
B	HOH388
B	HOH412
B	HOH746

---

site_id	AC5
Number of Residues	32
Details	BINDING SITE FOR RESIDUE NAD S 343

Chain	Residue
S	GLY26
S	PHE27
S	ILE28
S	LEU46
S	ASP47
S	ASN48
S	PHE49
S	SER50
S	THR51
S	GLY52
S	GLY77
S	ASP78
S	ILE79
S	GLN98
S	ALA99
S	ALA100
S	THR117
S	ALA140
S	ALA141
S	TYR166
S	LYS170
S	TYR193
S	ASN195
S	VAL196
S	HOH367
S	HOH372
S	HOH388
S	HOH393
S	HOH491
S	HOH500
S	GLY23
S	ALA25

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UDP S 344

Chain	Residue
S	ASN195
S	VAL210
S	LYS213
S	TRP214
S	TYR225
S	ILE226
S	ASN227
S	THR232
S	ARG234
S	LEU271
S	ARG299
S	ASP302
S	HOH380
S	HOH381
S	HOH463

---

site_id	AC7
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAD b 344

Chain	Residue
b	GLY23
b	ALA25
b	GLY26
b	PHE27
b	ILE28
b	ASP47
b	ASN48
b	PHE49
b	SER50
b	THR51
b	GLY52
b	GLY77
b	ASP78
b	ILE79
b	GLN98
b	ALA99
b	ALA100
b	THR117
b	ALA140
b	ALA141
b	TYR166
b	LYS170
b	TYR193
b	ASN195
b	VAL196
b	HOH356
b	HOH363
b	HOH381
b	HOH393
b	HOH401
b	HOH408
b	HOH412
b	HOH415

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UDP b 343

Chain	Residue
b	ASN195
b	ALA209
b	VAL210
b	LYS213
b	TRP214
b	TYR225
b	ASN227
b	THR232
b	ARG234
b	LEU271
b	ARG299
b	ASP302
b	HOH391
b	HOH394
b	HOH476

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 345

Chain	Residue
A	ARG4
A	LYS253
A	LYS318
B	HIS53
B	GLN54
B	TYR55

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21384454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21810411","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LU1","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RU7","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RU9","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUA","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUC","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUD","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUE","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUF","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUH","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21384454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21810411","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RUA","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3RUC","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21384454","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21810411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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