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3RT4

Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein

Replaces:  3MU9
Functional Information from GO Data
ChainGOidnamespacecontents
A0001818biological_processnegative regulation of cytokine production
A0005576cellular_componentextracellular region
A0008270molecular_functionzinc ion binding
A0008745molecular_functionN-acetylmuramoyl-L-alanine amidase activity
A0009253biological_processpeptidoglycan catabolic process
A0016019molecular_functionpeptidoglycan immune receptor activity
A0016045biological_processdetection of bacterium
A0042742biological_processdefense response to bacterium
A0042834molecular_functionpeptidoglycan binding
A0045087biological_processinnate immune response
A0050830biological_processdefense response to Gram-positive bacterium
B0001818biological_processnegative regulation of cytokine production
B0005576cellular_componentextracellular region
B0008270molecular_functionzinc ion binding
B0008745molecular_functionN-acetylmuramoyl-L-alanine amidase activity
B0009253biological_processpeptidoglycan catabolic process
B0016019molecular_functionpeptidoglycan immune receptor activity
B0016045biological_processdetection of bacterium
B0042742biological_processdefense response to bacterium
B0042834molecular_functionpeptidoglycan binding
B0045087biological_processinnate immune response
B0050830biological_processdefense response to Gram-positive bacterium
C0001818biological_processnegative regulation of cytokine production
C0005576cellular_componentextracellular region
C0008270molecular_functionzinc ion binding
C0008745molecular_functionN-acetylmuramoyl-L-alanine amidase activity
C0009253biological_processpeptidoglycan catabolic process
C0016019molecular_functionpeptidoglycan immune receptor activity
C0016045biological_processdetection of bacterium
C0042742biological_processdefense response to bacterium
C0042834molecular_functionpeptidoglycan binding
C0045087biological_processinnate immune response
C0050830biological_processdefense response to Gram-positive bacterium
D0001818biological_processnegative regulation of cytokine production
D0005576cellular_componentextracellular region
D0008270molecular_functionzinc ion binding
D0008745molecular_functionN-acetylmuramoyl-L-alanine amidase activity
D0009253biological_processpeptidoglycan catabolic process
D0016019molecular_functionpeptidoglycan immune receptor activity
D0016045biological_processdetection of bacterium
D0042742biological_processdefense response to bacterium
D0042834molecular_functionpeptidoglycan binding
D0045087biological_processinnate immune response
D0050830biological_processdefense response to Gram-positive bacterium
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE LP5 C 501
ChainResidue
AARG170
CASN99
CPRO100
CGLN150
CPRO151
CHOH178
CHOH208
CHOH421
DHIS93
DALA94
DGLY95
CLEU64
DPRO96
DTHR97
DTRP98
DASN99
DLYS144
DASP148
DVAL149
DGLN150
DPRO151
DHOH180
CTRP66
CLYS90
CALA92
CHIS93
CALA94
CGLY95
CPRO96

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE TLA C 6748
ChainResidue
CHIS37
CALA39
CTHR152
CLEU153
CSER154
CHOH257
CHOH287
CHOH399
CHOH631
DHIS37
DALA39
DTHR152
DLEU153
DSER154

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PDB entries from 2024-07-24

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