3RSL

H-Ras soaked in 90% R,S,R-bisfuranol: one of 10 in MSCS set

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GNP A 190

Chain	Residue
A	GLY12
A	ASP30
A	GLU31
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	GLN61
A	ASN116
A	LYS117
A	ASP119
A	GLY13
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	RSF206
A	RSF209
A	HOH301
A	HOH303
A	HOH304
A	HOH305
A	VAL14
A	MG592
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 203

Chain	Residue
A	GLN25
A	HIS27
A	TYR40
A	HOH310

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RSF A 204

Chain	Residue
A	PHE28
A	ASP30
A	LYS147
A	RSF211
A	HOH309

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 206

Chain	Residue
A	ASP30
A	TYR32
A	GNP190
A	RSF213

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 209

Chain	Residue
A	ASP30
A	HIS94
A	LYS147
A	GNP190

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RSF A 207

Chain	Residue
A	LEU23
A	LYS42
A	VAL44
A	ARG149
A	TYR157

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 211

Chain	Residue
A	ASP33
A	RSF204
A	RSF210
A	HOH309

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RSF A 208

Chain	Residue
A	GLY12
A	GLY13
A	TYR32
A	ASN86
A	RSF205

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 212

Chain	Residue
A	GLU37
A	ALA59
A	TYR96
A	GLN99

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 213

Chain	Residue
A	GLN95
A	GLN99
A	RSF206
A	HOH529

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RSF A 214

Chain	Residue
A	ILE46
A	ASP47
A	GLU143
A	GLN150
A	GLY151
A	TYR157
A	HOH318

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE RSF A 205

Chain	Residue
A	ALA11
A	GLY12
A	ASN86
A	LYS88
A	SER89
A	RSF208

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RSF A 215

Chain	Residue
A	ILE24
A	GLN25
A	ASP38
A	SER39
A	ARG41

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE RSF A 210

Chain	Residue
A	GLN25
A	ASN26
A	PRO34
A	RSF211

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 592

Chain	Residue
A	SER17
A	THR35
A	GNP190
A	HOH301
A	HOH303

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 591

Chain	Residue
A	ASP33
A	HOH309
A	HOH319
A	PHE28
A	ASP30
A	GLU31

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 596

Chain	Residue
A	GLU153
A	GLU153
A	ASP154
A	ASP154

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 593

Chain	Residue
A	ARG102
A	ARG102
A	ASP105
A	ASP105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:16698776

Chain	Residue	Details
A	GLY13
A	VAL29
A	ALA59
A	ASN116
A	SER145

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12

Chain	Residue	Details
A	THR2

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151

Chain	Residue	Details
A	CYS118

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667

Chain	Residue	Details
A	THR35

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