3RRZ

H-Ras in 70% glycerol: one of 10 in MSCS set

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GNP A 190

Chain	Residue
A	GLY12
A	ASP30
A	GLU31
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	GLN61
A	ASN116
A	LYS117
A	ASP119
A	GLY13
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG192
A	GOL219
A	HOH301
A	HOH303
A	HOH304
A	HOH305
A	VAL14
A	HOH334
A	HOH390
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	SER17
A	ILE21
A	HIS27
A	ASP33
A	THR35
A	ASP38
A	TYR40
A	GOL223
A	GOL223
A	HOH304
A	HOH310
A	HOH328

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 217

Chain	Residue
A	THR2
A	GLU3
A	GLU76
A	HOH343

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 205

Chain	Residue
A	ALA11
A	GLY12
A	ASN86
A	LYS88
A	HOH308

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 207

Chain	Residue
A	LEU23
A	ASN26
A	LYS42
A	ARG149
A	GLU153
A	TYR157

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 218

Chain	Residue
A	GLN22
A	ASN26
A	HIS27
A	ARG149

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 219

Chain	Residue
A	ASN85
A	HIS94
A	LYS117
A	LEU120
A	GNP190
A	HOH390
A	HOH491

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 223

Chain	Residue
A	ILE21
A	GLN25
A	HIS27
A	HIS27
A	VAL29
A	VAL29
A	TYR40
A	GOL203
A	GOL203
A	HOH328
A	HOH328

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 192

Chain	Residue
A	SER17
A	THR35
A	GNP190
A	HOH301
A	HOH303

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 193

Chain	Residue
A	PHE28
A	ASP30
A	GLU31
A	ASP33
A	HOH309
A	HOH319

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 195

Chain	Residue
A	ARG102
A	ARG102
A	ASP105
A	ASP105

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 194

Chain	Residue
A	HOH364
A	HOH364
A	HOH342
A	HOH342
A	HOH342
A	HOH364

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	HIS94
A	LEU120
A	ALA121
A	ALA122
A	TYR137
A	HOH491

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---