3RRO
Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG) from Vibrio cholerae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 249 |
| Chain | Residue |
| A | LYS103 |
| A | GLU104 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 250 |
| Chain | Residue |
| A | ARG19 |
| A | GLY20 |
| A | LYS23 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 251 |
| Chain | Residue |
| A | LYS132 |
| A | GLY82 |
| A | GLY83 |
| A | GLY83 |
| A | LYS132 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 252 |
| Chain | Residue |
| A | SER18 |
| A | ARG19 |
| A | ALA40 |
| A | THR41 |
| A | HOH313 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 253 |
| Chain | Residue |
| A | ARG133 |
| A | ARG176 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE A 254 |
| Chain | Residue |
| A | ASP96 |
| A | ALA150 |
| A | GLY151 |
| A | HOH361 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 255 |
| Chain | Residue |
| A | ILE248 |
| A | ILE248 |
| B | LYS167 |
| B | EDO259 |
| B | EDO259 |
| B | HOH305 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 256 |
| Chain | Residue |
| A | ARG19 |
| A | GLY20 |
| A | ILE21 |
| A | GLY22 |
| A | ASN90 |
| A | THR190 |
| A | EDO257 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 257 |
| Chain | Residue |
| A | ARG19 |
| A | GLY20 |
| A | THR190 |
| A | ASP191 |
| A | EDO256 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 258 |
| Chain | Residue |
| A | GLU8 |
| A | SER175 |
| A | ARG176 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 249 |
| Chain | Residue |
| B | LYS103 |
| B | GLU104 |
| B | HOH327 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 250 |
| Chain | Residue |
| A | SER2 |
| A | ARG32 |
| B | SER2 |
| B | ARG32 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 251 |
| Chain | Residue |
| B | ARG19 |
| B | GLY20 |
| B | LYS23 |
| B | LYS23 |
| B | EDO257 |
| B | HOH352 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 252 |
| Chain | Residue |
| B | GLY16 |
| B | ALA17 |
| B | SER18 |
| B | ALA40 |
| B | THR41 |
| B | HOH340 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 253 |
| Chain | Residue |
| B | ILE93 |
| B | ARG95 |
| B | HOH331 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 254 |
| Chain | Residue |
| B | ARG133 |
| B | ARG176 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 255 |
| Chain | Residue |
| B | GLY82 |
| B | GLY82 |
| B | GLY83 |
| B | GLY83 |
| B | LYS132 |
| B | LYS132 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 256 |
| Chain | Residue |
| A | LYS167 |
| B | ILE248 |
| B | ILE248 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 257 |
| Chain | Residue |
| B | ARG19 |
| B | GLY20 |
| B | THR190 |
| B | ASP191 |
| B | SO4251 |
| B | EDO258 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 258 |
| Chain | Residue |
| B | GLY16 |
| B | ARG19 |
| B | ILE21 |
| B | GLY22 |
| B | ASN90 |
| B | EDO257 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 259 |
| Chain | Residue |
| A | EDO255 |
| A | EDO255 |
| B | GLY145 |
| B | ILE163 |
| B | LYS167 |
| B | HOH305 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE B 260 |
| Chain | Residue |
| B | ASP96 |
| B | ASN97 |
| B | ALA150 |
| B | GLY151 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 261 |
| Chain | Residue |
| B | TYR155 |
| B | LYS159 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgtmgnagQanYAAAKAGViGFTkSMA |
| Chain | Residue | Details |
| A | SER142-ALA170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 |
| Chain | Residue | Details |
| A | TYR155 | |
| B | TYR155 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY16 | |
| B | ASN63 | |
| B | ASN90 | |
| B | SER142 | |
| B | TYR155 | |
| B | ILE188 | |
| A | THR41 | |
| A | ASN63 | |
| A | ASN90 | |
| A | SER142 | |
| A | TYR155 | |
| A | ILE188 | |
| B | GLY16 | |
| B | THR41 |
