3RQW
Crystal structure of acetylcholine bound to a prokaryotic pentameric ligand-gated ion channel, ELIC
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043005 | cellular_component | neuron projection |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042391 | biological_process | regulation of membrane potential |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043005 | cellular_component | neuron projection |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042391 | biological_process | regulation of membrane potential |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043005 | cellular_component | neuron projection |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043005 | cellular_component | neuron projection |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0007165 | biological_process | signal transduction |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0042391 | biological_process | regulation of membrane potential |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043005 | cellular_component | neuron projection |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0007165 | biological_process | signal transduction |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0042391 | biological_process | regulation of membrane potential |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043005 | cellular_component | neuron projection |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0007165 | biological_process | signal transduction |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0042391 | biological_process | regulation of membrane potential |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043005 | cellular_component | neuron projection |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0007165 | biological_process | signal transduction |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0042391 | biological_process | regulation of membrane potential |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043005 | cellular_component | neuron projection |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0007165 | biological_process | signal transduction |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0042391 | biological_process | regulation of membrane potential |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0043005 | cellular_component | neuron projection |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0007165 | biological_process | signal transduction |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0042391 | biological_process | regulation of membrane potential |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0043005 | cellular_component | neuron projection |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH A 323 |
| Chain | Residue |
| A | PHE19 |
| A | TYR38 |
| A | ASN103 |
| B | GLU131 |
| B | PRO132 |
| B | PHE133 |
| B | TYR175 |
| B | LEU178 |
| B | PHE188 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES A 324 |
| Chain | Residue |
| A | TRP206 |
| B | THR259 |
| B | GLN264 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 325 |
| Chain | Residue |
| A | PRO74 |
| A | LEU76 |
| A | TYR102 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 326 |
| Chain | Residue |
| A | ASN136 |
| A | ASN137 |
| A | GLN138 |
| A | ASP172 |
| A | GLU187 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH B 323 |
| Chain | Residue |
| B | PHE19 |
| B | TYR38 |
| B | ASN103 |
| C | GLU131 |
| C | PRO132 |
| C | PHE133 |
| C | TYR175 |
| C | LEU178 |
| C | PHE188 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES B 324 |
| Chain | Residue |
| B | TRP206 |
| C | THR259 |
| C | GLN264 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 325 |
| Chain | Residue |
| B | THR87 |
| B | GLY88 |
| C | SER84 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 326 |
| Chain | Residue |
| B | ARG174 |
| B | TYR175 |
| B | ASP176 |
| B | HIS177 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 327 |
| Chain | Residue |
| B | PRO11 |
| B | ASN136 |
| B | ASN137 |
| B | GLN138 |
| B | GLU187 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH C 323 |
| Chain | Residue |
| C | PHE19 |
| C | TYR38 |
| C | ASN103 |
| D | GLU131 |
| D | PRO132 |
| D | PHE133 |
| D | TYR175 |
| D | LEU178 |
| D | PHE188 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 324 |
| Chain | Residue |
| C | VAL73 |
| C | PRO74 |
| C | LYS90 |
| C | TYR102 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 325 |
| Chain | Residue |
| C | PRO11 |
| C | ASN136 |
| C | ASN137 |
| C | GLN138 |
| C | GLU187 |
| C | HOH326 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACH D 323 |
| Chain | Residue |
| D | PHE19 |
| D | TYR38 |
| D | ASN103 |
| E | GLU131 |
| E | PRO132 |
| E | PHE133 |
| E | TYR175 |
| E | PHE188 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES D 324 |
| Chain | Residue |
| C | TRP206 |
| D | THR259 |
| D | GLN264 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES D 325 |
| Chain | Residue |
| D | TRP206 |
| E | THR259 |
| E | GLN264 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 326 |
| Chain | Residue |
| D | PRO74 |
| D | LYS90 |
| D | TYR102 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 327 |
| Chain | Residue |
| D | ASN136 |
| D | ASN137 |
| D | GLN138 |
| D | ASP172 |
| D | GLU187 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH E 323 |
| Chain | Residue |
| A | GLU131 |
| A | PRO132 |
| A | PHE133 |
| A | TYR175 |
| A | LEU178 |
| A | PHE188 |
| E | PHE19 |
| E | TYR38 |
| E | ASN103 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MES E 324 |
| Chain | Residue |
| A | GLN264 |
| E | TRP206 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL E 325 |
| Chain | Residue |
| A | SER84 |
| E | THR87 |
| E | GLY88 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 326 |
| Chain | Residue |
| E | ASN136 |
| E | ASN137 |
| E | GLN138 |
| E | ASP172 |
| E | GLU187 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH F 323 |
| Chain | Residue |
| F | PHE19 |
| F | TYR38 |
| F | ASN103 |
| G | GLU131 |
| G | PRO132 |
| G | PHE133 |
| G | TYR175 |
| G | LEU178 |
| G | PHE188 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES F 324 |
| Chain | Residue |
| F | TRP206 |
| G | THR259 |
| G | GLN264 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL F 325 |
| Chain | Residue |
| F | PRO74 |
| F | LYS90 |
| F | TYR102 |
| F | GOL326 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL F 326 |
| Chain | Residue |
| F | THR87 |
| F | TYR102 |
| F | GOL325 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL F 327 |
| Chain | Residue |
| F | SER84 |
| J | GLY88 |
| J | ASN89 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL F 328 |
| Chain | Residue |
| F | PRO11 |
| F | ASN136 |
| F | ASN137 |
| F | GLN138 |
| F | GLU187 |
| site_id | DC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH G 323 |
| Chain | Residue |
| G | PHE19 |
| G | TYR38 |
| G | ASN103 |
| H | GLU131 |
| H | PRO132 |
| H | PHE133 |
| H | TYR175 |
| H | LEU178 |
| H | PHE188 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES G 324 |
| Chain | Residue |
| G | TRP206 |
| H | THR259 |
| H | GLN264 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL G 325 |
| Chain | Residue |
| G | GLY88 |
| G | ASN89 |
| H | SER84 |
| H | GOL325 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL G 326 |
| Chain | Residue |
| G | PRO74 |
| site_id | DC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL G 327 |
| Chain | Residue |
| G | SER109 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL G 328 |
| Chain | Residue |
| G | PRO11 |
| G | ASN136 |
| G | ASN137 |
| G | GLN138 |
| G | GLN185 |
| site_id | DC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH H 323 |
| Chain | Residue |
| H | PHE19 |
| H | TYR38 |
| H | ASN103 |
| I | GLU131 |
| I | PRO132 |
| I | PHE133 |
| I | TYR175 |
| I | LEU178 |
| I | PHE188 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL H 324 |
| Chain | Residue |
| H | PRO11 |
| H | ASN136 |
| H | ASN137 |
| H | GLN138 |
| H | GLN185 |
| H | GLU187 |
| H | HOH326 |
| site_id | DC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL H 325 |
| Chain | Residue |
| G | ASP36 |
| G | GLY88 |
| G | ARG105 |
| G | GOL325 |
| H | VAL81 |
| H | GLY83 |
| H | SER84 |
| site_id | EC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH I 323 |
| Chain | Residue |
| I | PHE19 |
| I | TYR38 |
| I | ASN103 |
| J | GLU131 |
| J | PRO132 |
| J | PHE133 |
| J | TYR175 |
| J | LEU178 |
| J | PHE188 |
| site_id | EC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MES I 324 |
| Chain | Residue |
| I | TRP206 |
| site_id | EC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL I 325 |
| Chain | Residue |
| I | THR259 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL I 326 |
| Chain | Residue |
| H | ASN60 |
| I | VAL73 |
| I | ALA75 |
| I | LYS90 |
| I | TYR102 |
| I | GOL327 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL I 327 |
| Chain | Residue |
| I | PRO74 |
| I | LEU76 |
| I | TYR102 |
| I | GOL326 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL I 328 |
| Chain | Residue |
| I | LYS34 |
| I | VAL82 |
| I | SER84 |
| I | PRO85 |
| I | GLY108 |
| I | SER109 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL I 329 |
| Chain | Residue |
| I | PRO11 |
| I | ASN136 |
| I | ASN137 |
| I | GLN138 |
| I | GLU187 |
| site_id | EC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACH J 323 |
| Chain | Residue |
| F | GLU131 |
| F | PRO132 |
| F | PHE133 |
| F | TYR175 |
| F | LEU178 |
| F | PHE188 |
| J | PHE19 |
| J | TYR38 |
| J | ASN103 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MES J 324 |
| Chain | Residue |
| F | THR259 |
| F | GLN264 |
| J | TRP206 |
| site_id | FC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL J 325 |
| Chain | Residue |
| J | PRO11 |
| J | ASN136 |
| J | ASN137 |
| J | GLN138 |
| J | GLU187 |
