Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RPN

Crystal structure of human kappa class glutathione transferase in complex with S-hexylglutathione

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001889	biological_process	liver development
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0010042	biological_process	response to manganese ion
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0030855	biological_process	epithelial cell differentiation
A	0046685	biological_process	response to arsenic-containing substance
A	0070062	cellular_component	extracellular exosome
A	0098869	biological_process	cellular oxidant detoxification
B	0001889	biological_process	liver development
B	0004364	molecular_function	glutathione transferase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0010042	biological_process	response to manganese ion
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0030855	biological_process	epithelial cell differentiation
B	0046685	biological_process	response to arsenic-containing substance
B	0070062	cellular_component	extracellular exosome
B	0098869	biological_process	cellular oxidant detoxification
C	0001889	biological_process	liver development
C	0004364	molecular_function	glutathione transferase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006749	biological_process	glutathione metabolic process
C	0010042	biological_process	response to manganese ion
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0030855	biological_process	epithelial cell differentiation
C	0046685	biological_process	response to arsenic-containing substance
C	0070062	cellular_component	extracellular exosome
C	0098869	biological_process	cellular oxidant detoxification
D	0001889	biological_process	liver development
D	0004364	molecular_function	glutathione transferase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006749	biological_process	glutathione metabolic process
D	0010042	biological_process	response to manganese ion
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0030855	biological_process	epithelial cell differentiation
D	0046685	biological_process	response to arsenic-containing substance
D	0070062	cellular_component	extracellular exosome
D	0098869	biological_process	cellular oxidant detoxification
E	0001889	biological_process	liver development
E	0004364	molecular_function	glutathione transferase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006749	biological_process	glutathione metabolic process
E	0010042	biological_process	response to manganese ion
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0030855	biological_process	epithelial cell differentiation
E	0046685	biological_process	response to arsenic-containing substance
E	0070062	cellular_component	extracellular exosome
E	0098869	biological_process	cellular oxidant detoxification
F	0001889	biological_process	liver development
F	0004364	molecular_function	glutathione transferase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006749	biological_process	glutathione metabolic process
F	0010042	biological_process	response to manganese ion
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0030855	biological_process	epithelial cell differentiation
F	0046685	biological_process	response to arsenic-containing substance
F	0070062	cellular_component	extracellular exosome
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GTX A 302

Chain	Residue
A	LEU15
A	MET91
A	PHE181
A	GLY182
A	LEU183
A	PHE198
A	GLY199
A	SER200
A	ASP201
A	HOH269
A	HOH670
A	SER16
D	LYS62
D	ARG202
A	PRO17
A	TYR18
A	ILE44
A	ASN53
A	PRO56
A	MET66
A	LEU88

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTX B 301

Chain	Residue
B	LEU15
B	SER16
B	PRO17
B	TYR18
B	ASN53
B	PRO56
B	LEU88
B	MET91
B	LEU92
B	PHE181
B	GLY182
B	LEU183
B	PHE198
B	GLY199
B	SER200
B	ASP201
E	LYS62
E	ARG202

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GTX C 301

Chain	Residue
C	LEU15
C	SER16
C	PRO17
C	TYR18
C	ILE44
C	ASN53
C	PRO56
C	MET91
C	LEU92
C	PHE181
C	GLY182
C	LEU183
C	PHE198
C	GLY199
C	SER200
C	ASP201
C	HOH365
C	HOH426
F	LYS62
F	ARG202

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GTX D 302

Chain	Residue
A	LYS62
A	ARG202
D	SER16
D	PRO17
D	TYR18
D	ILE44
D	ASN53
D	PRO56
D	MET66
D	LEU88
D	GLY182
D	LEU183
D	PHE198
D	GLY199
D	SER200
D	ASP201
D	HOH523
D	HOH530
D	HOH593

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GTX E 302

Chain	Residue
B	LYS62
B	ARG202
E	SER16
E	TYR18
E	ASN53
E	MET66
E	LEU88
E	GLY182
E	LEU183
E	PHE198
E	GLY199
E	SER200
E	ASP201
E	HOH337
E	HOH695

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GTX F 302

Chain	Residue
F	PRO56
F	MET66
F	LEU88
F	TRP126
F	GLY182
F	LEU183
F	PHE198
F	GLY199
F	SER200
F	ASP201
F	HOH241
C	LYS62
C	ARG202
F	SER16
F	PRO17
F	TYR18
F	ASN53

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16081649","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)