Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RKO

Crystal structure of the membrane domain of respiratory complex I from E. coli at 3.0 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0042773	biological_process	ATP synthesis coupled electron transport
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0042773	biological_process	ATP synthesis coupled electron transport
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0042773	biological_process	ATP synthesis coupled electron transport
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0005886	cellular_component	plasma membrane
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0030964	cellular_component	NADH dehydrogenase complex
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0048038	molecular_function	quinone binding
G	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0005886	cellular_component	plasma membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0048038	molecular_function	quinone binding
K	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0042773	biological_process	ATP synthesis coupled electron transport
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0042773	biological_process	ATP synthesis coupled electron transport
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0042773	biological_process	ATP synthesis coupled electron transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LFA L 614

Chain	Residue
L	LYS169
L	VAL173
L	PHE549

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LFA L 615

Chain	Residue
M	MET398
M	PRO399
M	LFA512
L	ALA19
L	ARG22
L	TYR119
L	LEU148
M	ALA386
M	LEU389

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LFA L 616

Chain	Residue
L	SER90
L	PHE340
L	LEU463

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CA7 M 510

Chain	Residue
L	MET168
L	PHE549
L	PHE553
L	LEU554
M	VAL434
M	HIS441
M	ARG442
M	PHE445
M	GLY446
M	LYS447

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LFA M 511

Chain	Residue
M	TYR221
M	ALA232
M	VAL237
M	VAL238
M	LEU240
M	LEU293

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LFA M 512

Chain	Residue
L	PHE20
L	LFA615
M	TRP383
M	ALA386
M	LEU387
M	PHE480

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LFA N 486

Chain	Residue
N	TRP408

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LFA N 487

Chain	Residue
N	VAL42
N	ILE43
N	ASN46
N	TYR92

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LFA N 488

Chain	Residue
N	MET74
N	LEU75
N	LEU480
N	ALA481

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LFA N 489

Chain	Residue
N	TRP408

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LFA B 614

Chain	Residue
B	LYS169
B	VAL172
B	VAL173
B	LEU235
B	PHE549
B	VAL550

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LFA B 615

Chain	Residue
B	ALA19
B	ARG22
B	TYR119
B	LEU148
C	ALA386
C	LEU389
C	MET398
C	PRO399
C	LFA513

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LFA B 616

Chain	Residue
B	SER90
B	PHE340
B	LEU463

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CA7 C 510

Chain	Residue
B	MET168
B	PHE553
B	LEU554
C	VAL434
C	HIS441
C	ARG442
C	PHE445
C	GLY446
C	LYS447

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LFA C 511

Chain	Residue
C	TYR221
C	ALA232
C	VAL237
C	VAL238
C	LEU240
C	LEU293

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LFA C 512

Chain	Residue
C	LEU223
D	TRP408

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LFA C 513

Chain	Residue
B	PHE20
B	LFA615
C	TRP383
C	ALA386
C	LEU387
C	PHE480

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LFA D 486

Chain	Residue
D	VAL42
D	ASN46
D	CYS88
D	THR89
D	TYR92

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LFA D 487

Chain	Residue
D	MET74
D	LEU75
D	ALA481

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LFA D 488

Chain	Residue
D	TRP408

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01456","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)