3RIS
Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0031011 | cellular_component | Ino80 complex |
| A | 0070628 | molecular_function | proteasome binding |
| B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0016579 | biological_process | protein deubiquitination |
| B | 0031011 | cellular_component | Ino80 complex |
| B | 0070628 | molecular_function | proteasome binding |
| C | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0016579 | biological_process | protein deubiquitination |
| C | 0031011 | cellular_component | Ino80 complex |
| C | 0070628 | molecular_function | proteasome binding |
| D | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| D | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| D | 0016579 | biological_process | protein deubiquitination |
| D | 0031011 | cellular_component | Ino80 complex |
| D | 0070628 | molecular_function | proteasome binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 241 |
| Chain | Residue |
| A | ARG137 |
| A | GLN138 |
| A | HOH252 |
| A | HOH291 |
| C | GLN146 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 241 |
| Chain | Residue |
| D | GLN146 |
| B | ARG137 |
| B | GLN138 |
| B | HOH248 |
| B | HOH269 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 242 |
| Chain | Residue |
| B | ARG174 |
| B | GLY189 |
| B | ALA190 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 241 |
| Chain | Residue |
| B | GLN146 |
| D | ARG137 |
| D | GLN138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for enzyme activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9WUP7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
