Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000118 | cellular_component | histone deacetylase complex |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009154 | biological_process | purine ribonucleotide catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016926 | biological_process | protein desumoylation |
| A | 0016929 | molecular_function | deSUMOylase activity |
| A | 0043530 | molecular_function | adenosine 5'-monophosphoramidase activity |
| A | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 5GP A 201 |
| Chain | Residue |
| A | ASN99 |
| A | GLY105 |
| A | GLN106 |
| A | SER107 |
| A | VAL108 |
| A | HIS112 |
| A | HIS114 |
| A | HOH219 |
| A | HOH235 |
| A | PHE19 |
| A | PHE41 |
| A | HIS42 |
| A | ASP43 |
| A | ILE44 |
| A | LEU53 |
| site_id | HIT |
| Number of Residues | 3 |
| Details | THE HISTIDINE TRIAD FORMS PART OF THE ALPHA PHOSPHATE-BINDING LOOP IN THE HIT PROTEIN SUPERFAMILY OF NUCLEOTIDE-BINDING PROTEINS. |
| Chain | Residue |
| A | HIS110 |
| A | HIS112 |
| A | HIS114 |
Functional Information from PROSITE/UniProt
| site_id | PS00892 |
| Number of Residues | 19 |
| Details | HIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG |
| Chain | Residue | Details |
| A | ASN99-GLY117 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 108 |
| Details | Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Histidine triad motif"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"UniProtKB","id":"P49773","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P49773","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P49773","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70349","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 5fit |
| Chain | Residue | Details |
| A | HIS112 | |
| A | ASN99 | |
| A | HIS110 | |
