Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004494 | molecular_function | methylmalonyl-CoA mutase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0016853 | molecular_function | isomerase activity |
A | 0016866 | molecular_function | intramolecular transferase activity |
A | 0019678 | biological_process | propionate metabolic process, methylmalonyl pathway |
A | 0031419 | molecular_function | cobalamin binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004494 | molecular_function | methylmalonyl-CoA mutase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0016853 | molecular_function | isomerase activity |
B | 0016866 | molecular_function | intramolecular transferase activity |
B | 0019652 | biological_process | lactate fermentation to propionate and acetate |
B | 0019678 | biological_process | propionate metabolic process, methylmalonyl pathway |
B | 0031419 | molecular_function | cobalamin binding |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE B12 A 800 |
Chain | Residue |
A | LEU119 |
A | ALA373 |
A | GLN454 |
A | ASP608 |
A | GLY609 |
A | HIS610 |
A | ASP611 |
A | ARG612 |
A | GLY613 |
A | ILE617 |
A | TYR621 |
A | VAL206 |
A | GLY653 |
A | SER655 |
A | LEU657 |
A | GLY685 |
A | GLY686 |
A | TYR705 |
A | THR706 |
A | PRO707 |
A | THR709 |
A | ADN801 |
A | ARG207 |
A | GLU247 |
A | GLY333 |
A | TRP334 |
A | GLU370 |
A | ALA371 |
A | ILE372 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ADN A 801 |
Chain | Residue |
A | TYR89 |
A | TYR243 |
A | GLU247 |
A | GLY333 |
A | TRP334 |
A | B12800 |
Functional Information from PROSITE/UniProt
site_id | PS00544 |
Number of Residues | 26 |
Details | METMALONYL_COA_MUTASE Methylmalonyl-CoA mutase signature. RIARNTgiVLaEEvnigRvnDPaGGS |
Chain | Residue | Details |
B | ARG377-SER402 | |
A | ARG381-SER406 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ALA76 | |
A | MET245 | |
A | LEU284 | |
A | PHE286 | |
A | TYR79 | |
A | PRO83 | |
A | ILE86 | |
A | GLN88 | |
A | ALA90 | |
A | VAL115 | |
A | ILE196 | |
A | ASN198 | |
Chain | Residue | Details |
A | ASP118 | |
A | GLY613 | |
A | SER656 | |
A | ALA658 | |
A | VAL687 | |
A | VAL710 | |
A | GLY140 | |
A | ARG207 | |
A | ASN208 | |
A | TRP334 | |
A | ALA371 | |
A | LEU374 | |
A | HIS610 | |
A | ARG612 | |
Chain | Residue | Details |
A | ASP611 | |
Chain | Residue | Details |
A | ALA90 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1bmt |
Chain | Residue | Details |
A | ASP608 | |
A | HIS661 | |
A | HIS610 | |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1bmt |
Chain | Residue | Details |
B | GLN208 | |
site_id | CSA3 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1bmt |
Chain | Residue | Details |
A | ASP608 | |
A | LYS604 | |
A | TYR89 | |
A | HIS244 | |
A | HIS610 | |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1bmt |
Chain | Residue | Details |
A | TYR621 | |
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 62 |
Chain | Residue | Details |
A | ALA90 | electrostatic stabiliser, radical stabiliser |
A | HIS244 | electrostatic stabiliser, radical stabiliser |
A | MET245 | electrostatic stabiliser, proton acceptor, proton donor |
A | MET605 | electrostatic stabiliser |
A | GLY609 | electrostatic stabiliser |
A | ASP611 | metal ligand |