Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3REI

2.65 Angstrom Crystal Structure of the Nucleosome Core Particle Assembled with a 145 bp Alpha-Satellite DNA (NCP145) Derivatized with Triamminechloroplatinum(II) Chloride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0031507	biological_process	heterochromatin formation
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031507	biological_process	heterochromatin formation
D	0046982	molecular_function	protein heterodimerization activity
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0031507	biological_process	heterochromatin formation
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031507	biological_process	heterochromatin formation
H	0046982	molecular_function	protein heterodimerization activity
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MN E 1001

Chain	Residue
D	VAL45
E	ASP77

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN H 1013

Chain	Residue
H	VAL45

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1101

Chain	Residue
C	GLY44
C	ALA45
C	GLY46
D	THR87
D	SER88

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 1102

Chain	Residue
G	ALA45
G	GLY46
G	ALA47
H	THR87
H	SER88
G	GLY44

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 1103

Chain	Residue
H	HIS46
H	PRO47
H	ASP48
H	THR49

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 73

Chain	Residue
I	DG60

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 73

Chain	Residue
J	DG60
J	DG61

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 74

Chain	Residue
I	DG7

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 74

Chain	Residue
J	DG7

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 75

Chain	Residue
J	DA-54
J	DG-55

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 76

Chain	Residue
J	DG-33

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 77

Chain	Residue
J	DG47

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 75

Chain	Residue
I	DG-55

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT I 76

Chain	Residue
I	DG-33
I	DG-34

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 77

Chain	Residue
I	DG-33

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 78

Chain	Residue
I	DG-2

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 78

Chain	Residue
J	DG-5

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 79

Chain	Residue
J	DG4

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PT I 79

Chain	Residue
I	DG63
I	DG64
I	PT84

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT B 103

Chain	Residue
B	MET84

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 80

Chain	Residue
I	DG4

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 80

Chain	Residue
J	DG-2

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 81

Chain	Residue
I	DA28

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 82

Chain	Residue
I	DG-15

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 83

Chain	Residue
I	DG-5

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT F 103

Chain	Residue
F	MET84
F	GLY101

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 82

Chain	Residue
J	DG23
J	DG24

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 83

Chain	Residue
I	DG-14
J	DG13

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PT I 84

Chain	Residue
I	DG63
I	DG64
I	PT79

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PT J 84

Chain	Residue
J	DG63
J	DG64
J	PT133

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 85

Chain	Residue
I	DG23

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 86

Chain	Residue
I	DG47

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 85

Chain	Residue
J	DG26
J	PT87

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 87

Chain	Residue
I	DT46

site_id	DC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 86

Chain	Residue
J	DA28

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT E 136

Chain	Residue
E	MET120
J	DG-2

site_id	EC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT A 136

Chain	Residue
A	LYS64
A	MET90

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT E 137

Chain	Residue
E	LYS64
E	MET90

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PT I 88

Chain	Residue
I	DT45
J	DA-43
J	DA-44

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT A 137

Chain	Residue
A	MET120
I	DG-2

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 87

Chain	Residue
I	DA67
J	PT85

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 89

Chain	Residue
I	DA25

site_id	EC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 88

Chain	Residue
J	DT46

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 89

Chain	Residue
J	DG-34
J	DG-33

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PT J 90

Chain	Residue
J	DA50
J	DG51
J	DT52

site_id	FC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 91

Chain	Residue
J	DG-58

site_id	FC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT I 90

Chain	Residue
I	DG-42
I	DA-43

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT J 92

Chain	Residue
J	DG-42
J	DT-41

site_id	FC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 93

Chain	Residue
J	DG-14

site_id	FC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PT C 130

Chain	Residue
C	ASN38
G	ASN38

site_id	FC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT I 91

Chain	Residue
I	DG26

site_id	FC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PT J 128

Chain	Residue
J	DA-72

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PT J 133

Chain	Residue
J	DG63
J	DG64
J	PT84

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P84228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	5
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	DNA binding: {}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P0C1H4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)