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3RE0

Crystal structure of human apo Cu,Zn superoxide dismutase (SOD1) complexed with cisplatin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0000303biological_processresponse to superoxide
A0001541biological_processovarian follicle development
A0001819biological_processpositive regulation of cytokine production
A0001890biological_processplacenta development
A0001895biological_processretina homeostasis
A0002262biological_processmyeloid cell homeostasis
A0004784molecular_functionsuperoxide dismutase activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007283biological_processspermatogenesis
A0007566biological_processembryo implantation
A0007605biological_processsensory perception of sound
A0007626biological_processlocomotory behavior
A0008089biological_processanterograde axonal transport
A0008090biological_processretrograde axonal transport
A0008217biological_processregulation of blood pressure
A0008270molecular_functionzinc ion binding
A0008340biological_processdetermination of adult lifespan
A0009408biological_processresponse to heat
A0009410biological_processresponse to xenobiotic stimulus
A0010033biological_processresponse to organic substance
A0010467biological_processgene expression
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019226biological_processtransmission of nerve impulse
A0019228biological_processneuronal action potential
A0019430biological_processremoval of superoxide radicals
A0030346molecular_functionprotein phosphatase 2B binding
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0032287biological_processperipheral nervous system myelin maintenance
A0032839cellular_componentdendrite cytoplasm
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033081biological_processregulation of T cell differentiation in thymus
A0035234biological_processectopic germ cell programmed cell death
A0040014biological_processregulation of multicellular organism growth
A0042542biological_processresponse to hydrogen peroxide
A0042554biological_processsuperoxide anion generation
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043085biological_processpositive regulation of catalytic activity
A0043087biological_processregulation of GTPase activity
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0045541biological_processnegative regulation of cholesterol biosynthetic process
A0045859biological_processregulation of protein kinase activity
A0046620biological_processregulation of organ growth
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048538biological_processthymus development
A0048678biological_processresponse to axon injury
A0050665biological_processhydrogen peroxide biosynthetic process
A0050728biological_processnegative regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0051087molecular_functionprotein-folding chaperone binding
A0051093biological_processnegative regulation of developmental process
A0051881biological_processregulation of mitochondrial membrane potential
A0060047biological_processheart contraction
A0060052biological_processneurofilament cytoskeleton organization
A0060087biological_processrelaxation of vascular associated smooth muscle
A0060088biological_processauditory receptor cell stereocilium organization
A0070062cellular_componentextracellular exosome
A0072593biological_processreactive oxygen species metabolic process
A0099610biological_processaction potential initiation
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1904115cellular_componentaxon cytoplasm
A2000242biological_processnegative regulation of reproductive process
B0000302biological_processresponse to reactive oxygen species
B0000303biological_processresponse to superoxide
B0001541biological_processovarian follicle development
B0001819biological_processpositive regulation of cytokine production
B0001890biological_processplacenta development
B0001895biological_processretina homeostasis
B0002262biological_processmyeloid cell homeostasis
B0004784molecular_functionsuperoxide dismutase activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0005759cellular_componentmitochondrial matrix
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006749biological_processglutathione metabolic process
B0006801biological_processsuperoxide metabolic process
B0006879biological_processintracellular iron ion homeostasis
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0007283biological_processspermatogenesis
B0007566biological_processembryo implantation
B0007605biological_processsensory perception of sound
B0007626biological_processlocomotory behavior
B0008089biological_processanterograde axonal transport
B0008090biological_processretrograde axonal transport
B0008217biological_processregulation of blood pressure
B0008270molecular_functionzinc ion binding
B0008340biological_processdetermination of adult lifespan
B0009408biological_processresponse to heat
B0009410biological_processresponse to xenobiotic stimulus
B0010033biological_processresponse to organic substance
B0010467biological_processgene expression
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0019226biological_processtransmission of nerve impulse
B0019228biological_processneuronal action potential
B0019430biological_processremoval of superoxide radicals
B0030346molecular_functionprotein phosphatase 2B binding
B0031267molecular_functionsmall GTPase binding
B0031410cellular_componentcytoplasmic vesicle
B0032287biological_processperipheral nervous system myelin maintenance
B0032839cellular_componentdendrite cytoplasm
B0032930biological_processpositive regulation of superoxide anion generation
B0032991cellular_componentprotein-containing complex
B0033081biological_processregulation of T cell differentiation in thymus
B0035234biological_processectopic germ cell programmed cell death
B0040014biological_processregulation of multicellular organism growth
B0042542biological_processresponse to hydrogen peroxide
B0042554biological_processsuperoxide anion generation
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043085biological_processpositive regulation of catalytic activity
B0043087biological_processregulation of GTPase activity
B0043410biological_processpositive regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0045541biological_processnegative regulation of cholesterol biosynthetic process
B0045859biological_processregulation of protein kinase activity
B0046620biological_processregulation of organ growth
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048538biological_processthymus development
B0048678biological_processresponse to axon injury
B0050665biological_processhydrogen peroxide biosynthetic process
B0050728biological_processnegative regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0051087molecular_functionprotein-folding chaperone binding
B0051093biological_processnegative regulation of developmental process
B0051881biological_processregulation of mitochondrial membrane potential
B0060047biological_processheart contraction
B0060052biological_processneurofilament cytoskeleton organization
B0060087biological_processrelaxation of vascular associated smooth muscle
B0060088biological_processauditory receptor cell stereocilium organization
B0070062cellular_componentextracellular exosome
B0072593biological_processreactive oxygen species metabolic process
B0099610biological_processaction potential initiation
B1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1904115cellular_componentaxon cytoplasm
B2000242biological_processnegative regulation of reproductive process
C0000302biological_processresponse to reactive oxygen species
C0000303biological_processresponse to superoxide
C0001541biological_processovarian follicle development
C0001819biological_processpositive regulation of cytokine production
C0001890biological_processplacenta development
C0001895biological_processretina homeostasis
C0002262biological_processmyeloid cell homeostasis
C0004784molecular_functionsuperoxide dismutase activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005758cellular_componentmitochondrial intermembrane space
C0005759cellular_componentmitochondrial matrix
C0005777cellular_componentperoxisome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006749biological_processglutathione metabolic process
C0006801biological_processsuperoxide metabolic process
C0006879biological_processintracellular iron ion homeostasis
C0006915biological_processapoptotic process
C0006979biological_processresponse to oxidative stress
C0007283biological_processspermatogenesis
C0007566biological_processembryo implantation
C0007605biological_processsensory perception of sound
C0007626biological_processlocomotory behavior
C0008089biological_processanterograde axonal transport
C0008090biological_processretrograde axonal transport
C0008217biological_processregulation of blood pressure
C0008270molecular_functionzinc ion binding
C0008340biological_processdetermination of adult lifespan
C0009408biological_processresponse to heat
C0009410biological_processresponse to xenobiotic stimulus
C0010033biological_processresponse to organic substance
C0010467biological_processgene expression
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019226biological_processtransmission of nerve impulse
C0019228biological_processneuronal action potential
C0019430biological_processremoval of superoxide radicals
C0030346molecular_functionprotein phosphatase 2B binding
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0032287biological_processperipheral nervous system myelin maintenance
C0032839cellular_componentdendrite cytoplasm
C0032930biological_processpositive regulation of superoxide anion generation
C0032991cellular_componentprotein-containing complex
C0033081biological_processregulation of T cell differentiation in thymus
C0035234biological_processectopic germ cell programmed cell death
C0040014biological_processregulation of multicellular organism growth
C0042542biological_processresponse to hydrogen peroxide
C0042554biological_processsuperoxide anion generation
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043085biological_processpositive regulation of catalytic activity
C0043087biological_processregulation of GTPase activity
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0045541biological_processnegative regulation of cholesterol biosynthetic process
C0045859biological_processregulation of protein kinase activity
C0046620biological_processregulation of organ growth
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048538biological_processthymus development
C0048678biological_processresponse to axon injury
C0050665biological_processhydrogen peroxide biosynthetic process
C0050728biological_processnegative regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0051087molecular_functionprotein-folding chaperone binding
C0051093biological_processnegative regulation of developmental process
C0051881biological_processregulation of mitochondrial membrane potential
C0060047biological_processheart contraction
C0060052biological_processneurofilament cytoskeleton organization
C0060087biological_processrelaxation of vascular associated smooth muscle
C0060088biological_processauditory receptor cell stereocilium organization
C0070062cellular_componentextracellular exosome
C0072593biological_processreactive oxygen species metabolic process
C0099610biological_processaction potential initiation
C1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1904115cellular_componentaxon cytoplasm
C2000242biological_processnegative regulation of reproductive process
D0000302biological_processresponse to reactive oxygen species
D0000303biological_processresponse to superoxide
D0001541biological_processovarian follicle development
D0001819biological_processpositive regulation of cytokine production
D0001890biological_processplacenta development
D0001895biological_processretina homeostasis
D0002262biological_processmyeloid cell homeostasis
D0004784molecular_functionsuperoxide dismutase activity
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005758cellular_componentmitochondrial intermembrane space
D0005759cellular_componentmitochondrial matrix
D0005777cellular_componentperoxisome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006749biological_processglutathione metabolic process
D0006801biological_processsuperoxide metabolic process
D0006879biological_processintracellular iron ion homeostasis
D0006915biological_processapoptotic process
D0006979biological_processresponse to oxidative stress
D0007283biological_processspermatogenesis
D0007566biological_processembryo implantation
D0007605biological_processsensory perception of sound
D0007626biological_processlocomotory behavior
D0008089biological_processanterograde axonal transport
D0008090biological_processretrograde axonal transport
D0008217biological_processregulation of blood pressure
D0008270molecular_functionzinc ion binding
D0008340biological_processdetermination of adult lifespan
D0009408biological_processresponse to heat
D0009410biological_processresponse to xenobiotic stimulus
D0010033biological_processresponse to organic substance
D0010467biological_processgene expression
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0019226biological_processtransmission of nerve impulse
D0019228biological_processneuronal action potential
D0019430biological_processremoval of superoxide radicals
D0030346molecular_functionprotein phosphatase 2B binding
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0032287biological_processperipheral nervous system myelin maintenance
D0032839cellular_componentdendrite cytoplasm
D0032930biological_processpositive regulation of superoxide anion generation
D0032991cellular_componentprotein-containing complex
D0033081biological_processregulation of T cell differentiation in thymus
D0035234biological_processectopic germ cell programmed cell death
D0040014biological_processregulation of multicellular organism growth
D0042542biological_processresponse to hydrogen peroxide
D0042554biological_processsuperoxide anion generation
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043085biological_processpositive regulation of catalytic activity
D0043087biological_processregulation of GTPase activity
D0043410biological_processpositive regulation of MAPK cascade
D0043524biological_processnegative regulation of neuron apoptotic process
D0045471biological_processresponse to ethanol
D0045541biological_processnegative regulation of cholesterol biosynthetic process
D0045859biological_processregulation of protein kinase activity
D0046620biological_processregulation of organ growth
D0046716biological_processmuscle cell cellular homeostasis
D0046872molecular_functionmetal ion binding
D0048538biological_processthymus development
D0048678biological_processresponse to axon injury
D0050665biological_processhydrogen peroxide biosynthetic process
D0050728biological_processnegative regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0051087molecular_functionprotein-folding chaperone binding
D0051093biological_processnegative regulation of developmental process
D0051881biological_processregulation of mitochondrial membrane potential
D0060047biological_processheart contraction
D0060052biological_processneurofilament cytoskeleton organization
D0060087biological_processrelaxation of vascular associated smooth muscle
D0060088biological_processauditory receptor cell stereocilium organization
D0070062cellular_componentextracellular exosome
D0072593biological_processreactive oxygen species metabolic process
D0099610biological_processaction potential initiation
D1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1904115cellular_componentaxon cytoplasm
D2000242biological_processnegative regulation of reproductive process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CPT B 201
ChainResidue
ALEU106
ACYS111
BLEU106
BCYS111

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CPT B 202
ChainResidue
BASP109
CGLU24

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CPT C 201
ChainResidue
CCYS111
DCYS111
DILE113

Functional Information from PROSITE/UniProt
site_idPS00087
Number of Residues11
DetailsSOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT
ChainResidueDetails
AGLY44-THR54

site_idPS00332
Number of Residues12
DetailsSOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI
ChainResidueDetails
AGLY138-ILE149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:12963370, ECO:0000269|PubMed:17548825
ChainResidueDetails
AHIS46
DHIS46
DHIS48
DHIS120
AHIS48
AHIS120
BHIS46
BHIS48
BHIS120
CHIS46
CHIS48
CHIS120

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:20727846
ChainResidueDetails
AHIS63
CHIS71
CHIS80
CASP83
DHIS63
DHIS71
DHIS80
DASP83
AHIS71
AHIS80
AASP83
BHIS63
BHIS71
BHIS80
BASP83
CHIS63

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:1463506, ECO:0000269|PubMed:7002610, ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
ALYS3
DLYS3
DLYS9
DLYS91
ALYS9
ALYS91
BLYS3
BLYS9
BLYS91
CLYS3
CLYS9
CLYS91

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER98
BSER98
CSER98
DSER98

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER102
BSER102
CSER102
DSER102

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07632
ChainResidueDetails
ASER105
BSER105
CSER105
DSER105

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
ASER107
BSER107
CSER107
DSER107

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:24140062
ChainResidueDetails
ALYS122
BLYS122
CLYS122
DLYS122

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P08228
ChainResidueDetails
ALYS136
BLYS136
CLYS136
DLYS136

site_idSWS_FT_FI11
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22496122
ChainResidueDetails
ACYS6
BCYS6
CCYS6
DCYS6

site_idSWS_FT_FI12
Number of Residues8
DetailsCROSSLNK: 1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33) => ECO:0000269|PubMed:20600836
ChainResidueDetails
ATRP32
BTRP32
CTRP32
DTRP32

218853

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