Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RBC

Bullfrog M ferritin with iron(III) bound to the ferroxidase site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005737	cellular_component	cytoplasm
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
B	0004322	molecular_function	ferroxidase activity
B	0005737	cellular_component	cytoplasm
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
C	0004322	molecular_function	ferroxidase activity
C	0005737	cellular_component	cytoplasm
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
D	0004322	molecular_function	ferroxidase activity
D	0005737	cellular_component	cytoplasm
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
E	0004322	molecular_function	ferroxidase activity
E	0005737	cellular_component	cytoplasm
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
F	0004322	molecular_function	ferroxidase activity
F	0005737	cellular_component	cytoplasm
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0016491	molecular_function	oxidoreductase activity
F	0046872	molecular_function	metal ion binding
G	0004322	molecular_function	ferroxidase activity
G	0005737	cellular_component	cytoplasm
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0016491	molecular_function	oxidoreductase activity
G	0046872	molecular_function	metal ion binding
H	0004322	molecular_function	ferroxidase activity
H	0005737	cellular_component	cytoplasm
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0016491	molecular_function	oxidoreductase activity
H	0046872	molecular_function	metal ion binding
I	0004322	molecular_function	ferroxidase activity
I	0005737	cellular_component	cytoplasm
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0016491	molecular_function	oxidoreductase activity
I	0046872	molecular_function	metal ion binding
J	0004322	molecular_function	ferroxidase activity
J	0005737	cellular_component	cytoplasm
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0016491	molecular_function	oxidoreductase activity
J	0046872	molecular_function	metal ion binding
K	0004322	molecular_function	ferroxidase activity
K	0005737	cellular_component	cytoplasm
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0016491	molecular_function	oxidoreductase activity
K	0046872	molecular_function	metal ion binding
L	0004322	molecular_function	ferroxidase activity
L	0005737	cellular_component	cytoplasm
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0016491	molecular_function	oxidoreductase activity
L	0046872	molecular_function	metal ion binding
M	0004322	molecular_function	ferroxidase activity
M	0005737	cellular_component	cytoplasm
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0016491	molecular_function	oxidoreductase activity
M	0046872	molecular_function	metal ion binding
N	0004322	molecular_function	ferroxidase activity
N	0005737	cellular_component	cytoplasm
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0016491	molecular_function	oxidoreductase activity
N	0046872	molecular_function	metal ion binding
O	0004322	molecular_function	ferroxidase activity
O	0005737	cellular_component	cytoplasm
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0016491	molecular_function	oxidoreductase activity
O	0046872	molecular_function	metal ion binding
P	0004322	molecular_function	ferroxidase activity
P	0005737	cellular_component	cytoplasm
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0016491	molecular_function	oxidoreductase activity
P	0046872	molecular_function	metal ion binding
Q	0004322	molecular_function	ferroxidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0016491	molecular_function	oxidoreductase activity
Q	0046872	molecular_function	metal ion binding
R	0004322	molecular_function	ferroxidase activity
R	0005737	cellular_component	cytoplasm
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0016491	molecular_function	oxidoreductase activity
R	0046872	molecular_function	metal ion binding
S	0004322	molecular_function	ferroxidase activity
S	0005737	cellular_component	cytoplasm
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0016491	molecular_function	oxidoreductase activity
S	0046872	molecular_function	metal ion binding
T	0004322	molecular_function	ferroxidase activity
T	0005737	cellular_component	cytoplasm
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0016491	molecular_function	oxidoreductase activity
T	0046872	molecular_function	metal ion binding
U	0004322	molecular_function	ferroxidase activity
U	0005737	cellular_component	cytoplasm
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008198	molecular_function	ferrous iron binding
U	0008199	molecular_function	ferric iron binding
U	0016491	molecular_function	oxidoreductase activity
U	0046872	molecular_function	metal ion binding
V	0004322	molecular_function	ferroxidase activity
V	0005737	cellular_component	cytoplasm
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008198	molecular_function	ferrous iron binding
V	0008199	molecular_function	ferric iron binding
V	0016491	molecular_function	oxidoreductase activity
V	0046872	molecular_function	metal ion binding
W	0004322	molecular_function	ferroxidase activity
W	0005737	cellular_component	cytoplasm
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008198	molecular_function	ferrous iron binding
W	0008199	molecular_function	ferric iron binding
W	0016491	molecular_function	oxidoreductase activity
W	0046872	molecular_function	metal ion binding
X	0004322	molecular_function	ferroxidase activity
X	0005737	cellular_component	cytoplasm
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008198	molecular_function	ferrous iron binding
X	0008199	molecular_function	ferric iron binding
X	0016491	molecular_function	oxidoreductase activity
X	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE A 180

Chain	Residue
A	GLU23
A	GLU58
A	HIS61
A	GLN137
A	FE181
A	HOH1511
A	HOH1512

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE A 181

Chain	Residue
A	GLN137
A	HOH176
A	FE180
A	HOH1510
A	HOH1512
A	GLU58
A	GLU103

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE B 180

Chain	Residue
B	GLU23
B	GLU58
B	HIS61
B	GLN137
B	FE181
B	HOH1513

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE B 181

Chain	Residue
B	GLU58
B	GLU103
B	GLN137
B	FE180
B	HOH183
B	HOH1513

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE C 180

Chain	Residue
C	GLU23
C	GLU58
C	HIS61
C	GLN137
C	FE181
C	HOH1514
C	HOH1515

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE C 181

Chain	Residue
C	GLU58
C	GLU103
C	GLN137
C	HOH177
C	FE180
C	HOH1514

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE D 180

Chain	Residue
D	GLU23
D	GLU58
D	HIS61
D	GLN137
D	FE181
D	HOH1516
D	HOH1517

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE D 181

Chain	Residue
D	GLU58
D	GLU103
D	GLN137
D	ASP140
D	FE180
D	HOH391
D	HOH1516

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE E 180

Chain	Residue
E	GLU58
E	GLU103
E	GLN137
E	ASP140
E	FE181
E	HOH1518

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE E 181

Chain	Residue
E	GLU23
E	GLU58
E	HIS61
E	GLN137
E	FE180
E	HOH1518

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE F 180

Chain	Residue
F	GLU23
F	GLU58
F	HIS61
F	GLN137
F	FE181
F	HOH1519

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE F 181

Chain	Residue
F	GLU58
F	GLU103
F	GLN137
F	ASP140
F	FE180
F	HOH235
F	HOH1519

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE G 180

Chain	Residue
G	GLU58
G	GLU103
G	GLN137
G	FE181
G	HOH1520

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE G 181

Chain	Residue
G	GLU23
G	GLU58
G	HIS61
G	GLN137
G	FE180

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE H 180

Chain	Residue
H	GLU23
H	GLU58
H	HIS61
H	GLN137
H	FE181
H	HOH1521

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE H 181

Chain	Residue
H	HOH211
H	HOH1521
H	GLU58
H	GLU103
H	GLN137
H	ASP140
H	FE180

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE H 176

Chain	Residue
A	GLU130
A	HOH893
H	ASP127
H	GLU130
X	ASP127
X	GLU130

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE I 180

Chain	Residue
I	GLU23
I	GLU58
I	HIS61
I	GLN137
I	FE181
I	HOH1522
I	HOH1524

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE I 181

Chain	Residue
I	GLU58
I	GLU103
I	GLN137
I	HOH178
I	FE180
I	HOH1522
I	HOH1523

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE J 180

Chain	Residue
J	GLU23
J	GLU58
J	HIS61
J	GLN137
J	FE181
J	HOH1525
J	HOH1526

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE J 181

Chain	Residue
J	GLU58
J	GLU103
J	GLN137
J	HOH179
J	FE180
J	HOH1525

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE K 180

Chain	Residue
K	GLU23
K	GLU58
K	HIS61
K	GLN137
K	FE181
K	HOH1527

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE K 181

Chain	Residue
K	GLU58
K	GLU103
K	GLN137
K	ASP140
K	FE180
K	HOH1527

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE L 180

Chain	Residue
L	GLU23
L	GLU58
L	HIS61
L	GLN137
L	FE181
L	HOH1528

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE L 181

Chain	Residue
L	GLU58
L	GLU103
L	GLN137
L	FE180
L	HOH182
L	HOH1528

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE L 176

Chain	Residue
L	ASP127
L	GLU130
M	ASP127
M	GLU130
T	ASP127
T	GLU130
T	HOH182

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE M 180

Chain	Residue
M	GLU58
M	GLU103
M	GLN137
M	ASP140
M	HOH176
M	FE181
M	HOH1529

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE M 181

Chain	Residue
M	GLU23
M	GLU58
M	HIS61
M	GLN137
M	FE180
M	HOH1529

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE N 180

Chain	Residue
N	GLU58
N	GLU103
N	GLN137
N	FE181
N	HOH1345
N	HOH1530

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE N 181

Chain	Residue
N	GLU23
N	GLU58
N	HIS61
N	GLN137
N	FE180
N	HOH1530
N	HOH1531

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE O 180

Chain	Residue
O	GLU23
O	GLU58
O	HIS61
O	GLN137
O	FE181
O	HOH1532
O	HOH1533

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE O 181

Chain	Residue
O	GLU58
O	GLU103
O	GLN137
O	ASP140
O	FE180

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE P 180

Chain	Residue
P	GLU23
P	GLU58
P	HIS61
P	GLN137
P	FE181
P	HOH1534

site_id	DC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FE P 181

Chain	Residue
P	GLU58
P	GLU103
P	GLN137
P	ASP140
P	FE180
P	HOH1413
P	HOH1417
P	HOH1534

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE Q 180

Chain	Residue
Q	GLU23
Q	GLU58
Q	HIS61
Q	GLN137
Q	FE181
Q	HOH1535
Q	HOH1536

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE Q 181

Chain	Residue
Q	GLU58
Q	GLU103
Q	GLN137
Q	HOH177
Q	FE180
Q	HOH1535

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE R 180

Chain	Residue
R	GLU23
R	GLU58
R	HIS61
R	GLN137
R	FE181
R	HOH1537

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE R 181

Chain	Residue
R	GLU58
R	GLU103
R	GLN137
R	ASP140
R	FE180
R	HOH380
R	HOH1537

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE S 180

Chain	Residue
S	GLU23
S	GLU58
S	HIS61
S	GLN137
S	FE181
S	HOH1538
S	HOH1539

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE S 181

Chain	Residue
S	GLU58
S	GLU103
S	GLN137
S	FE180
S	HOH182
S	HOH1538

site_id	EC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE T 180

Chain	Residue
T	GLU23
T	GLU58
T	HIS61
T	GLN137
T	FE181
T	HOH1540

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE T 181

Chain	Residue
T	GLU58
T	GLU103
T	GLN137
T	FE180
T	HOH431
T	HOH1540

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE U 180

Chain	Residue
U	GLU23
U	GLU58
U	HIS61
U	GLN137
U	FE181
U	HOH1541

site_id	EC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE U 181

Chain	Residue
U	GLU58
U	GLU103
U	GLN137
U	ASP140
U	FE180
U	HOH1404
U	HOH1541

site_id	EC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE V 180

Chain	Residue
V	GLU23
V	GLU58
V	HIS61
V	GLN137
V	FE181
V	HOH1542
V	HOH1543

site_id	FC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE V 181

Chain	Residue
V	GLU58
V	GLU103
V	GLN137
V	ASP140
V	FE180
V	HOH280
V	HOH1542

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE W 180

Chain	Residue
W	GLU23
W	GLU58
W	HIS61
W	GLN137
W	FE181
W	HOH1546

site_id	FC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE W 181

Chain	Residue
W	GLU58
W	GLU103
W	GLN137
W	FE180
W	HOH262
W	HOH1546

site_id	FC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE X 180

Chain	Residue
X	GLU23
X	GLU58
X	HIS61
X	GLN137
X	FE181
X	HOH1544
X	HOH1545

site_id	FC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FE X 181

Chain	Residue
X	GLU58
X	GLU103
X	GLN137
X	ASP140
X	HOH177
X	FE180
X	HOH604
X	HOH1544

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEseYLeeqvkdIK

Chain	Residue	Details
A	ASP122-LYS142

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKFMkyQNkRgGR

Chain	Residue	Details
A	GLU57-ARG75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3576
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	144
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)