3RAS
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with a lipophilic phosphonate inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
A | 0030145 | molecular_function | manganese ion binding |
A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0050897 | molecular_function | cobalt ion binding |
A | 0051483 | biological_process | terpenoid biosynthetic process, mevalonate-independent |
A | 0051484 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process |
A | 0070402 | molecular_function | NADPH binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
B | 0030145 | molecular_function | manganese ion binding |
B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0050897 | molecular_function | cobalt ion binding |
B | 0051483 | biological_process | terpenoid biosynthetic process, mevalonate-independent |
B | 0051484 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process |
B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NDP A 1391 |
Chain | Residue |
A | GLY19 |
A | HIS50 |
A | ALA69 |
A | ALA103 |
A | LEU104 |
A | LEU108 |
A | ALA126 |
A | ASN127 |
A | LYS128 |
A | GLU129 |
A | ASP151 |
A | THR21 |
A | MET205 |
A | GLY206 |
A | PRO207 |
A | ASN209 |
A | MET267 |
A | FM5390 |
A | DCV391 |
A | HOH399 |
A | GLY22 |
A | SER23 |
A | ILE24 |
A | ALA46 |
A | GLY47 |
A | GLY48 |
A | ALA49 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE FM5 A 390 |
Chain | Residue |
A | ASP151 |
A | SER152 |
A | GLU153 |
A | ALA176 |
A | SER177 |
A | TRP203 |
A | MET205 |
A | ASN209 |
A | SER213 |
A | ASN218 |
A | LYS219 |
A | GLU222 |
A | SER245 |
A | DCV391 |
A | MN392 |
A | NDP1391 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE DCV A 391 |
Chain | Residue |
A | LYS128 |
A | ASP151 |
A | SER152 |
A | ALA176 |
A | SER177 |
A | TRP203 |
A | MET205 |
A | ASN209 |
A | SER213 |
A | ASN218 |
A | LYS219 |
A | GLU222 |
A | SER245 |
A | FM5390 |
A | MN392 |
A | NDP1391 |
site_id | AC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE NDP B 1392 |
Chain | Residue |
B | GLY19 |
B | THR21 |
B | GLY22 |
B | SER23 |
B | ILE24 |
B | ALA46 |
B | GLY47 |
B | GLY48 |
B | ALA49 |
B | HIS50 |
B | ALA69 |
B | ALA103 |
B | LEU104 |
B | LEU108 |
B | ALA126 |
B | ASN127 |
B | LYS128 |
B | ASP151 |
B | MET267 |
B | HOH397 |
B | HOH422 |
B | HOH423 |
B | HOH434 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 392 |
Chain | Residue |
A | ASP151 |
A | GLU153 |
A | GLU222 |
A | FM5390 |
A | DCV391 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE FM5 B 390 |
Chain | Residue |
B | THR21 |
B | HIS50 |
B | THR53 |
B | TRP203 |
B | DCV391 |
B | HOH412 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DCV B 391 |
Chain | Residue |
B | HIS50 |
B | THR53 |
B | TRP203 |
B | FM5390 |
B | HOH395 |
B | HOH412 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B 392 |
Chain | Residue |
B | ASP151 |
B | GLU153 |
B | GLU222 |
B | HOH462 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 393 |
Chain | Residue |
B | ALA176 |
B | SER177 |
B | SER213 |
B | ASN218 |
B | LYS219 |
B | HOH444 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 36 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00183 |
Chain | Residue | Details |
A | THR21 | |
A | SER152 | |
A | GLU153 | |
A | SER177 | |
A | HIS200 | |
A | GLY206 | |
A | SER213 | |
A | ASN218 | |
A | LYS219 | |
A | GLU222 | |
B | THR21 | |
A | GLY22 | |
B | GLY22 | |
B | SER23 | |
B | ILE24 | |
B | GLY47 | |
B | ASN127 | |
B | LYS128 | |
B | GLU129 | |
B | ASP151 | |
B | SER152 | |
B | GLU153 | |
A | SER23 | |
B | SER177 | |
B | HIS200 | |
B | GLY206 | |
B | SER213 | |
B | ASN218 | |
B | LYS219 | |
B | GLU222 | |
A | ILE24 | |
A | GLY47 | |
A | ASN127 | |
A | LYS128 | |
A | GLU129 | |
A | ASP151 |