Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RAP

The small G protein Rap2 in a non catalytic complex with GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0000287	molecular_function	magnesium ion binding
R	0001934	biological_process	positive regulation of protein phosphorylation
R	0003924	molecular_function	GTPase activity
R	0003925	molecular_function	G protein activity
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005768	cellular_component	endosome
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0008104	biological_process	protein localization
R	0016020	cellular_component	membrane
R	0016787	molecular_function	hydrolase activity
R	0019003	molecular_function	GDP binding
R	0030033	biological_process	microvillus assembly
R	0030036	biological_process	actin cytoskeleton organization
R	0030336	biological_process	negative regulation of cell migration
R	0030496	cellular_component	midbody
R	0030659	cellular_component	cytoplasmic vesicle membrane
R	0031954	biological_process	positive regulation of protein autophosphorylation
R	0032486	biological_process	Rap protein signal transduction
R	0045184	biological_process	establishment of protein localization
R	0045198	biological_process	establishment of epithelial cell apical/basal polarity
R	0045202	cellular_component	synapse
R	0046328	biological_process	regulation of JNK cascade
R	0048814	biological_process	regulation of dendrite morphogenesis
R	0051963	biological_process	regulation of synapse assembly
R	0055037	cellular_component	recycling endosome
R	0055038	cellular_component	recycling endosome membrane
R	0071466	biological_process	cellular response to xenobiotic stimulus
R	0072659	biological_process	protein localization to plasma membrane
R	0097060	cellular_component	synaptic membrane
R	0098588	cellular_component	bounding membrane of organelle
R	0098685	cellular_component	Schaffer collateral - CA1 synapse
R	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
S	0000287	molecular_function	magnesium ion binding
S	0001934	biological_process	positive regulation of protein phosphorylation
S	0003924	molecular_function	GTPase activity
S	0003925	molecular_function	G protein activity
S	0005515	molecular_function	protein binding
S	0005525	molecular_function	GTP binding
S	0005768	cellular_component	endosome
S	0005829	cellular_component	cytosol
S	0005886	cellular_component	plasma membrane
S	0007165	biological_process	signal transduction
S	0008104	biological_process	protein localization
S	0016020	cellular_component	membrane
S	0016787	molecular_function	hydrolase activity
S	0019003	molecular_function	GDP binding
S	0030033	biological_process	microvillus assembly
S	0030036	biological_process	actin cytoskeleton organization
S	0030336	biological_process	negative regulation of cell migration
S	0030496	cellular_component	midbody
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0031954	biological_process	positive regulation of protein autophosphorylation
S	0032486	biological_process	Rap protein signal transduction
S	0045184	biological_process	establishment of protein localization
S	0045198	biological_process	establishment of epithelial cell apical/basal polarity
S	0045202	cellular_component	synapse
S	0046328	biological_process	regulation of JNK cascade
S	0048814	biological_process	regulation of dendrite morphogenesis
S	0051963	biological_process	regulation of synapse assembly
S	0055037	cellular_component	recycling endosome
S	0055038	cellular_component	recycling endosome membrane
S	0071466	biological_process	cellular response to xenobiotic stimulus
S	0072659	biological_process	protein localization to plasma membrane
S	0097060	cellular_component	synaptic membrane
S	0098588	cellular_component	bounding membrane of organelle
S	0098685	cellular_component	Schaffer collateral - CA1 synapse
S	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG R 200

Chain	Residue
R	SER17
R	THR35
R	GTP180
R	HOH201
R	HOH202

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG S 201

Chain	Residue
S	HOH203
S	SER17
S	THR35
S	GTP181
S	HOH202

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP R 180

Chain	Residue
R	GLY13
R	VAL14
R	GLY15
R	LYS16
R	SER17
R	ALA18
R	PHE28
R	ILE29
R	GLU30
R	TYR32
R	PRO34
R	THR35
R	GLY60
R	THR61
R	ASN116
R	LYS117
R	ASP119
R	LEU120
R	SER146
R	ALA147
R	MG200
R	HOH201
R	HOH202
R	HOH207
R	HOH218

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GTP S 181

Chain	Residue
S	GLY12
S	GLY13
S	VAL14
S	GLY15
S	LYS16
S	SER17
S	ALA18
S	PHE28
S	ILE29
S	GLU30
S	TYR32
S	PRO34
S	THR35
S	GLY60
S	THR61
S	ASN116
S	LYS117
S	ASP119
S	LEU120
S	SER146
S	ALA147
S	MG201
S	HOH202
S	HOH203
S	HOH214
S	HOH221
S	HOH227

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
R	GLY10
R	ASP57
R	ASN116
S	GLY10
S	ASP57
S	ASN116

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxin TcdA, and by P.sordellii toxin TcsL => ECO:0000269\|PubMed:22267739, ECO:0000269\|PubMed:8626586

Chain	Residue	Details
R	THR35
S	THR35

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
R	THR61

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
S	THR61

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)