3R8D

Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PNU A 1

Chain	Residue
A	LEU240
A	MET243
A	SER247
A	GLN285
A	PHE288
A	TRP299
A	LEU411
A	PHE420
A	MET425

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12578355, ECO:0007744|PDB:1M13

Chain	Residue	Details
A	SER247
A	GLN285
A	HIS407

---