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3R7W

Crystal Structure of Gtr1p-Gtr2p complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000329cellular_componentfungal-type vacuole membrane
A0000781cellular_componentchromosome, telomeric region
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005770cellular_componentlate endosome
A0005773cellular_componentvacuole
A0005774cellular_componentvacuolar membrane
A0006360biological_processtranscription by RNA polymerase I
A0006383biological_processtranscription by RNA polymerase III
A0006817biological_processphosphate ion transport
A0006995biological_processcellular response to nitrogen starvation
A0009267biological_processcellular response to starvation
A0010507biological_processnegative regulation of autophagy
A0016020cellular_componentmembrane
A0016237biological_processmicroautophagy
A0016787molecular_functionhydrolase activity
A0031509biological_processsubtelomeric heterochromatin formation
A0031902cellular_componentlate endosome membrane
A0032008biological_processpositive regulation of TOR signaling
A0032456biological_processendocytic recycling
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0071230biological_processcellular response to amino acid stimulus
A0071986cellular_componentRagulator complex
A1903778biological_processprotein localization to vacuolar membrane
A1904263biological_processpositive regulation of TORC1 signaling
A1990131cellular_componentGtr1-Gtr2 GTPase complex
B0000329cellular_componentfungal-type vacuole membrane
B0000785cellular_componentchromatin
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005770cellular_componentlate endosome
B0005773cellular_componentvacuole
B0005774cellular_componentvacuolar membrane
B0006995biological_processcellular response to nitrogen starvation
B0009267biological_processcellular response to starvation
B0010507biological_processnegative regulation of autophagy
B0016020cellular_componentmembrane
B0016237biological_processmicroautophagy
B0016787molecular_functionhydrolase activity
B0031902cellular_componentlate endosome membrane
B0032008biological_processpositive regulation of TOR signaling
B0032456biological_processendocytic recycling
B0034599biological_processcellular response to oxidative stress
B0045121cellular_componentmembrane raft
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0071230biological_processcellular response to amino acid stimulus
B0071986cellular_componentRagulator complex
B1903778biological_processprotein localization to vacuolar membrane
B1904263biological_processpositive regulation of TORC1 signaling
B1990131cellular_componentGtr1-Gtr2 GTPase complex
C0000329cellular_componentfungal-type vacuole membrane
C0000781cellular_componentchromosome, telomeric region
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005770cellular_componentlate endosome
C0005773cellular_componentvacuole
C0005774cellular_componentvacuolar membrane
C0006360biological_processtranscription by RNA polymerase I
C0006383biological_processtranscription by RNA polymerase III
C0006817biological_processphosphate ion transport
C0006995biological_processcellular response to nitrogen starvation
C0009267biological_processcellular response to starvation
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0016237biological_processmicroautophagy
C0016787molecular_functionhydrolase activity
C0031509biological_processsubtelomeric heterochromatin formation
C0031902cellular_componentlate endosome membrane
C0032008biological_processpositive regulation of TOR signaling
C0032456biological_processendocytic recycling
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0071230biological_processcellular response to amino acid stimulus
C0071986cellular_componentRagulator complex
C1903778biological_processprotein localization to vacuolar membrane
C1904263biological_processpositive regulation of TORC1 signaling
C1990131cellular_componentGtr1-Gtr2 GTPase complex
D0000329cellular_componentfungal-type vacuole membrane
D0000785cellular_componentchromatin
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005770cellular_componentlate endosome
D0005773cellular_componentvacuole
D0005774cellular_componentvacuolar membrane
D0006995biological_processcellular response to nitrogen starvation
D0009267biological_processcellular response to starvation
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0016237biological_processmicroautophagy
D0016787molecular_functionhydrolase activity
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0032456biological_processendocytic recycling
D0034599biological_processcellular response to oxidative stress
D0045121cellular_componentmembrane raft
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D1903778biological_processprotein localization to vacuolar membrane
D1904263biological_processpositive regulation of TORC1 signaling
D1990131cellular_componentGtr1-Gtr2 GTPase complex
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GNP A 500
ChainResidue
ASER15
AGLY64
AHIS126
ALYS127
AASP129
ALEU130
ASER165
AILE166
ATRP167
AMG600
AHOH701
AGLY16
AHOH702
ASER17
AGLY18
ALYS19
ASER20
ASER21
ATHR35
ATHR41

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 600
ChainResidue
ASER20
ATHR41
AGNP500
AHOH701
AHOH702

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GNP B 500
ChainResidue
BARG18
BARG19
BCYS20
BGLY21
BLYS22
BSER23
BSER24
BTHR38
BLEU39
BSER43
BGLU62
BGLY65
BHIS124
BLYS125
BASP127
BSER165
BILE166
BMG600

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 600
ChainResidue
BSER23
BTHR44
BGLU62
BGNP500

site_idAC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GNP C 500
ChainResidue
CSER15
CGLY16
CSER17
CGLY18
CLYS19
CSER20
CSER21
CTHR35
CTHR41
CGLY64
CHIS126
CLYS127
CASP129
CLEU130
CSER165
CILE166
CMG600
CHOH701
CHOH702

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C 600
ChainResidue
CSER20
CTHR41
CGNP500
CHOH701
CHOH702

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GNP D 500
ChainResidue
DCYS20
DGLY21
DLYS22
DSER23
DSER24
DHIS124
DLYS125
DILE166
DMG600

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 600
ChainResidue
DLYS22
DSER23
DGNP500

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:21816923, ECO:0007744|PDB:3R7W
ChainResidueDetails
BSER23
DASP127
AILE166
CSER15
CGLY18
CLYS19
CSER20
CSER21
CTHR35
CTHR41
CGLY64
BSER24
CHIS126
CASP129
CILE166
BSER43
BHIS124
BASP127
DSER23
DSER24
DSER43
DHIS124

224572

PDB entries from 2024-09-04

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