3R7L

Crystal Structure of PALA-bound Aspartate Transcarbamoylase from Bacillus subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
D	0004070	molecular_function	aspartate carbamoyltransferase activity
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
E	0004070	molecular_function	aspartate carbamoyltransferase activity
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
F	0004070	molecular_function	aspartate carbamoyltransferase activity
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PAL A 311

Chain	Residue
A	SER47
A	ALA250
A	HOH331
A	HOH341
A	HOH343
B	SER74
B	LYS77
A	THR48
A	ARG49
A	THR50
A	ARG99
A	HIS127
A	ARG160
A	ARG211
A	GLN213

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PAL B 312

Chain	Residue
B	SER47
B	THR48
B	ARG49
B	THR50
B	ARG99
B	HIS127
B	ARG160
B	ARG211
B	GLN213
B	ALA250
B	HOH310
B	HOH326
B	HOH341
C	SER74
C	LYS77

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 305

Chain	Residue
A	LYS59
B	LYS59
B	HOH305
C	LYS59
C	HOH311
C	HOH332
C	HOH425

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PAL C 313

Chain	Residue
A	SER74
A	LYS77
C	SER47
C	THR48
C	ARG49
C	THR50
C	ARG99
C	HIS127
C	ARG160
C	ARG211
C	GLN213
C	ALA250
C	HOH309
C	HOH323
C	HOH342

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 305

Chain	Residue
D	LYS59
D	HOH476
D	HOH493
E	LYS59
F	LYS59
F	HOH308
F	HOH320

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PAL D 314

Chain	Residue
D	SER47
D	THR48
D	ARG49
D	THR50
D	ARG99
D	HIS127
D	GLN130
D	ARG160
D	ARG211
D	GLN213
D	ALA250
D	HOH311
D	HOH313
D	HOH317
E	SER74
E	LYS77

---

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PAL E 315

Chain	Residue
E	SER47
E	THR48
E	ARG49
E	THR50
E	ARG99
E	HIS127
E	ARG160
E	ARG211
E	GLN213
E	ALA250
E	HOH318
E	HOH320
E	HOH387
F	SER74
F	LYS77

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PAL F 316

Chain	Residue
F	ARG211
F	GLN213
F	ALA250
F	HOH315
F	HOH326
F	HOH568
D	SER74
D	LYS77
F	SER47
F	THR48
F	ARG49
F	THR50
F	ARG99
F	HIS127
F	ARG160

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEpSTRT

Chain	Residue	Details
A	PHE43-THR50

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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