3R7F

Crystal Structure of CP-bound Aspartate Transcarbamoylase from Bacillus subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CP A 802

Chain	Residue
A	SER47
A	HOH511
B	SER74
A	THR48
A	ARG49
A	THR50
A	ARG99
A	HIS127
A	GLN130
A	PRO249
A	ALA250

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 305

Chain	Residue
A	ASN67
A	HOH438
A	HOH446
A	HOH447
A	HOH478
A	HOH604
A	HOH606
B	ASN67
C	ASN67
C	HOH340

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 306

Chain	Residue
A	LYS59
A	HOH317
A	HOH344
A	HOH478
A	HOH497
A	HOH604
A	HOH606
B	LYS59
C	LYS59

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 307

Chain	Residue
A	SER11
A	THR12
A	ARG171
A	HOH418

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 308

Chain	Residue
A	GLN23
A	LYS26
A	GLU140
A	LYS272
A	HOH463

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 309

Chain	Residue
A	LYS272
A	LYS275
A	HOH406
A	HOH424
A	HOH429
A	HOH468

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 310

Chain	Residue
A	LYS241
A	ARG242
A	HIS243
A	HOH379
A	HOH403

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CP B 802

Chain	Residue
B	SER47
B	THR48
B	ARG49
B	THR50
B	ARG99
B	HIS127
B	GLN130
B	PRO249
B	ALA250

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 305

Chain	Residue
B	GLN23
B	LYS26
B	GLU140
B	LYS272
B	HOH380

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 306

Chain	Residue
B	SER11
B	THR12
B	ARG171
B	HOH411

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 307

Chain	Residue
B	LYS272
B	LYS275
B	HOH392
B	HOH393
B	HOH414
B	HOH459

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CP B 308

Chain	Residue
A	HOH329
B	THR144
B	PHE145
B	LYS146
B	HOH350
B	HOH368
B	HOH501

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CP C 802

Chain	Residue
C	SER47
C	THR48
C	ARG49
C	THR50
C	ARG99
C	HIS127
C	GLN130
C	PRO249
C	ALA250

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 305

Chain	Residue
C	GLN23
C	LYS26
C	GLU140
C	LYS272
C	HOH572

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 306

Chain	Residue
C	HOH389
C	HOH405
C	LYS272
C	LYS275
C	HOH382
C	HOH383

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 307

Chain	Residue
C	SER11
C	THR12
C	ARG171
C	HOH363
C	HOH615

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 308

Chain	Residue
C	LYS16
C	TYR139
C	THR144
C	PHE145
C	LYS146
C	HOH359
C	HOH621

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEpSTRT

Chain	Residue	Details
A	PHE43-THR50

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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