3R6W

paAzoR1 binding to nitrofurazone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003960	molecular_function	quinone reductase (NADPH) activity
A	0006979	biological_process	response to oxidative stress
A	0009055	molecular_function	electron transfer activity
A	0010181	molecular_function	FMN binding
A	0016652	molecular_function	oxidoreductase activity, acting on NAD(P)H as acceptor
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
B	0003960	molecular_function	quinone reductase (NADPH) activity
B	0006979	biological_process	response to oxidative stress
B	0009055	molecular_function	electron transfer activity
B	0010181	molecular_function	FMN binding
B	0016652	molecular_function	oxidoreductase activity, acting on NAD(P)H as acceptor
B	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN A 1213

Chain	Residue
A	SER10
A	PHE100
A	SER145
A	ARG146
A	GLY147
A	GLY148
A	PHE151
A	GLU187
A	GLU188
A	NFZ213
A	HOH223
A	ARG12
A	HOH276
B	VAL56
A	SER16
A	GLN17
A	SER18
A	PRO96
A	MET97
A	TYR98
A	ASN99

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NFZ A 213

Chain	Residue
A	ASN99
A	PHE100
A	PHE151
A	GLU188
A	HOH316
A	HOH356
A	FMN1213
B	PHE60
B	VAL114
B	PHE120
B	TYR131
B	PHE173

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NFZ A 214

Chain	Residue
A	PHE60
A	VAL114
A	PHE120
A	TYR131
A	PHE173
A	HOH253
A	HOH327
B	ASN99
B	FMN1213

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 215

Chain	Residue
A	ARG30
A	ARG40
A	HOH331

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 216

Chain	Residue
A	GLU14
A	SER68
A	LEU69
A	ALA70
A	HOH227
A	HOH275
A	HOH317

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 217

Chain	Residue
A	PRO47
A	LEU48
A	SER104
A	GLY105
A	HOH255
A	HOH278
B	SER104

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 218

Chain	Residue
A	ARG40
A	ARG41
A	ALA76
A	LEU77
A	GLN80
A	HOH260
A	HOH271
A	HOH325
A	HOH358
A	HOH360

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 219

Chain	Residue
A	ARG3
A	ALA39
A	GLU84
A	ASP87
A	HOH285
A	HOH295

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 220

Chain	Residue
A	ARG139
A	ALA140
A	LEU141
A	GLU178
A	ALA212
A	HOH228
A	HOH347

---

site_id	BC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE FMN B 1213

Chain	Residue
B	GOL213
B	HOH242
B	HOH274
A	NFZ214
B	SER10
B	ARG12
B	SER16
B	GLN17
B	SER18
B	PRO96
B	MET97
B	TYR98
B	ASN99
B	PHE100
B	SER145
B	ARG146
B	GLY147
B	GLY148
B	PHE151
B	GLU187

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 213

Chain	Residue
B	ARG12
B	GLU187
B	HOH242
B	FMN1213

---

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL B 214

Chain	Residue
B	ARG40
B	GLU42
B	LEU69
B	GLN72
B	ALA73
B	ALA76
B	HOH223
B	HOH233
B	HOH253
B	HOH286
B	HOH324

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01216","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17904577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20057057","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22355582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N9Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22355582","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R6W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22355582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N9Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20057057","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important in the architecture of the active site","evidences":[{"source":"PubMed","id":"20057057","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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