Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | ASP184 |
| A | ASP212 |
| A | ASN213 |
| A | LU1307 |
| A | HOH634 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 302 |
| Chain | Residue |
| A | ASN84 |
| A | VAL85 |
| A | SER115 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 303 |
| Chain | Residue |
| A | ALA88 |
| A | TYR243 |
| A | ASP87 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 304 |
| Chain | Residue |
| A | ILE134 |
| A | GLN163 |
| A | ARG189 |
| A | HOH649 |
| A | HOH653 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 305 |
| Chain | Residue |
| A | PRO125 |
| A | GLY126 |
| A | ARG128 |
| A | LYS154 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 306 |
| Chain | Residue |
| A | ASP46 |
| A | THR47 |
| A | LYS48 |
| A | ARG51 |
| A | HOH478 |
| A | HOH615 |
| site_id | AC7 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE LU1 A 307 |
| Chain | Residue |
| A | MET83 |
| A | GLY109 |
| A | GLU133 |
| A | ILE134 |
| A | ASN135 |
| A | ALA140 |
| A | GLN143 |
| A | GLN144 |
| A | GLY160 |
| A | ALA161 |
| A | SER162 |
| A | GLN163 |
| A | ASP184 |
| A | HIS185 |
| A | TRP186 |
| A | LYS187 |
| A | ARG189 |
| A | ASP212 |
| A | ASN213 |
| A | PRO217 |
| A | LEU241 |
| A | GLU242 |
| A | MG301 |
| A | HOH438 |
| A | HOH483 |
| A | HOH529 |
| A | HOH534 |
| A | HOH634 |
| A | HOH677 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE DTD A 308 |
| Chain | Residue |
| A | LEU195 |
| A | GLU198 |
| A | TYR225 |
| A | SER231 |
| A | PHE232 |
| A | TYR240 |
| A | HOH420 |
| A | HOH506 |
| A | HOH583 |
| A | HOH690 |
| A | HOH716 |
| A | HOH716 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NHE A 309 |
| Chain | Residue |
| A | GLU80 |
| A | TRP81 |
| A | ALA139 |
| A | GLN143 |
| A | ILE157 |
| A | MET244 |
| A | HOH424 |
| A | HOH445 |
| A | HOH447 |
| A | HOH470 |
| A | HOH471 |
| A | HOH622 |
| A | HOH633 |
| A | HOH717 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12237326","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| A | ASP184 | metal ligand |
| A | LYS187 | proton shuttle (general acid/base) |
| A | ASP212 | metal ligand |
| A | ASN213 | metal ligand |
| A | GLU242 | electrostatic stabiliser |
