3R6B

Crystal Structure of Thrombospondin-1 TSR Domains 2 and 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005615	cellular_component	extracellular space
A	0008201	molecular_function	heparin binding
A	0016525	biological_process	negative regulation of angiogenesis
A	0050840	molecular_function	extracellular matrix binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1

Chain	Residue
A	EDO2
A	HOH34
A	HOH35

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2

Chain	Residue
A	EDO1
A	SER442
A	TRP444
A	ARG458
A	LEU518
A	HOH583

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 3

Chain	Residue
A	CYS447
A	ILE456
A	LYS486

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 4

Chain	Residue
A	ASN463
A	ASP487
A	ALA488
A	ASN521

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	ARG460
A	GLU475

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 6

Chain	Residue
A	HIS440
A	GLN525

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 7

Chain	Residue
A	MET469
A	ARG517

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 8

Chain	Residue
A	HOH39
A	PRO497
A	TRP498

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	55
Details	Domain: {"description":"TSP type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	55
Details	Domain: {"description":"TSP type-1 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"C-linked (Man) tryptophan","featureId":"CAR_000207","evidences":[{"source":"PubMed","id":"11067851","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"C-linked (Man) tryptophan","featureId":"CAR_000208","evidences":[{"source":"PubMed","id":"11067851","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Fuc...) threonine","featureId":"CAR_000209","evidences":[{"source":"PubMed","id":"11067851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12391027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"C-linked (Man) tryptophan","featureId":"CAR_000210","evidences":[{"source":"PubMed","id":"11067851","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Fuc...) threonine","featureId":"CAR_000211","evidences":[{"source":"PubMed","id":"11067851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12391027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---