3R2Y
MK2 kinase bound to Compound 1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MLI A 365 |
| Chain | Residue |
| A | LYS55 |
| A | TYR63 |
| A | ASN83 |
| A | ARG85 |
| A | ARG85 |
| A | ASP122 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLI A 366 |
| Chain | Residue |
| A | ASN75 |
| A | LYS93 |
| A | ASP186 |
| A | ASP207 |
| A | P4O3 |
| A | GLY73 |
| A | ILE74 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE P4O A 3 |
| Chain | Residue |
| A | LEU70 |
| A | LEU72 |
| A | ALA91 |
| A | LYS93 |
| A | MET138 |
| A | GLU139 |
| A | LEU141 |
| A | ASP142 |
| A | LEU193 |
| A | ASP207 |
| A | MLI366 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK |
| Chain | Residue | Details |
| A | LEU70-LYS93 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY |
| Chain | Residue | Details |
| A | ILE182-TYR194 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
