3R0L
Crystal structure of crotoxin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004623 | molecular_function | phospholipase A2 activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0006644 | biological_process | phospholipid metabolic process |
A | 0016042 | biological_process | lipid catabolic process |
A | 0050482 | biological_process | arachidonic acid secretion |
B | 0004623 | molecular_function | phospholipase A2 activity |
B | 0006644 | biological_process | phospholipid metabolic process |
B | 0050482 | biological_process | arachidonic acid secretion |
D | 0004623 | molecular_function | phospholipase A2 activity |
D | 0005509 | molecular_function | calcium ion binding |
D | 0005543 | molecular_function | phospholipid binding |
D | 0005576 | cellular_component | extracellular region |
D | 0006644 | biological_process | phospholipid metabolic process |
D | 0016042 | biological_process | lipid catabolic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0035821 | biological_process | modulation of process of another organism |
D | 0042130 | biological_process | negative regulation of T cell proliferation |
D | 0046872 | molecular_function | metal ion binding |
D | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
D | 0050482 | biological_process | arachidonic acid secretion |
D | 0090729 | molecular_function | toxin activity |
D | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL B 126 |
Chain | Residue |
B | HOH54 |
B | ILE73 |
B | VAL74 |
D | ASP112 |
D | HOH181 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN D 123 |
Chain | Residue |
D | ASP62 |
D | GLU82 |
D | HOH187 |
D | HOH203 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D 124 |
Chain | Residue |
D | PHE23 |
D | GLY25 |
D | TYR110 |
D | ASP112 |
D | HOH131 |
D | HOH157 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA D 125 |
Chain | Residue |
D | TYR27 |
D | GLY29 |
D | GLY31 |
D | ASP48 |
D | HOH247 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT D 127 |
Chain | Residue |
D | PHE5 |
D | CYS28 |
D | GLY29 |
D | CYS44 |
D | HIS47 |
D | HOH277 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P62022 |
Chain | Residue | Details |
D | HIS47 | |
D | ASP89 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P62022 |
Chain | Residue | Details |
D | TYR27 | |
D | GLY29 | |
D | GLY31 | |
D | ASP48 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Important for stability and high toxicity => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | HIS1 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | SITE: Putative interfacial binding surface (IBS) => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | LEU2 | |
D | VAL18 | |
D | LEU3 | |
D | LYS7 | |
D | LYS10 | |
D | ALA17 | |
D | ALA22 | |
D | PHE23 | |
D | LYS60 | |
D | TYR103 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Responsible for the higher anticoagulant activity (compared with CBa2) => ECO:0000269|PubMed:18062812 |
Chain | Residue | Details |
D | GLY117 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Binds Q-49 of CBa2 => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | ARG14 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Binds G-45 of CBa2 => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | ASN16 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Binds D-105 of CBa2, important for stability (T-31) => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | TRP30 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | SITE: Binds E-93 of CBa2 => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | GLY31 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | SITE: Binds D-95 of CBa2, important for stability (T-70) => ECO:0000269|PubMed:21787789 |
Chain | Residue | Details |
D | TRP61 |