Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE MTX A 2000 |
| Chain | Residue |
| A | VAL4 |
| A | ARG74 |
| A | ASP75 |
| A | ASN79 |
| A | THR80 |
| A | VAL81 |
| A | ALA100 |
| A | HOH1005 |
| A | HOH1064 |
| A | HOH1118 |
| B | ARG58 |
| A | CYS24 |
| A | ALA26 |
| A | ARG28 |
| A | ARG29 |
| A | SER30 |
| A | SER31 |
| A | ARG32 |
| A | TRP34 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 132 |
| Chain | Residue |
| A | ARG74 |
| A | HOH1023 |
| A | HOH1026 |
| A | HOH1098 |
| A | HOH1106 |
| A | HOH1120 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 133 |
| Chain | Residue |
| A | ASP101 |
| A | ASP102 |
| A | GLY112 |
| A | ASP119 |
| A | HOH1018 |
| A | HOH1066 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTX B 2000 |
| Chain | Residue |
| B | VAL4 |
| B | CYS24 |
| B | ALA26 |
| B | ARG28 |
| B | ARG29 |
| B | SER30 |
| B | SER31 |
| B | ARG32 |
| B | TRP34 |
| B | MET36 |
| B | ARG74 |
| B | ASP75 |
| B | ASN79 |
| B | THR80 |
| B | VAL81 |
| B | ALA100 |
| B | HOH1022 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 132 |
| Chain | Residue |
| B | ASP101 |
| B | ASP102 |
| B | GLY112 |
| B | ASP119 |
| B | NA133 |
| B | HOH1044 |
| B | HOH1087 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 133 |
| Chain | Residue |
| B | SER111 |
| B | GLY112 |
| B | NA132 |
| B | HOH1017 |
| B | HOH1044 |
| B | HOH1055 |
| B | HOH1083 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 134 |
| Chain | Residue |
| B | ARG74 |
| B | HOH1018 |
| B | HOH1034 |
| B | HOH1048 |
| B | HOH1075 |
