3QXS

Crystal structure of dethiobiotin synthetase (BioD) from Helicobacter pylori complexed with ANP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004141	molecular_function	dethiobiotin synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009102	biological_process	biotin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 221

Chain	Residue
A	HIS147
A	ASN149
A	HOH419

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ANP A 222

Chain	Residue
A	THR15
A	LYS35
A	ASP50
A	GLU116
A	GLN167
A	ASN175
A	LYS177
A	MG223
A	HOH243
A	HOH255
A	HOH286
A	HOH289
A	HOH299
A	HOH302
A	HOH321
A	HOH370
A	HOH437
A	HOH455
A	HOH485
A	THR9
A	ASN10
A	ALA11
A	GLY12
A	LYS13
A	THR14

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 223

Chain	Residue
A	THR14
A	ASP50
A	GLU116
A	ANP222
A	HOH455

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 224

Chain	Residue
A	ASN130
A	LEU132
A	ASP133
A	HIS166
A	EDO234

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NO3 A 225

Chain	Residue
A	SER5
A	ALA6
A	LYS13
A	GLY117
A	ALA118
A	GLY119
A	GLY120
A	LEU121
A	HOH285

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 226

Chain	Residue
A	PHE72
A	TYR73
A	ARG74
A	TYR75
A	HOH294
A	HOH445
A	HOH481

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 227

Chain	Residue
A	CYS122
A	GLU129
A	ASN130
A	LEU157
A	TYR190
A	EDO234
A	HOH392
A	HOH545

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 228

Chain	Residue
A	ASP111
A	HOH305
A	HOH412
A	HOH491

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 229

Chain	Residue
A	THR181
A	ASN195
A	ASN199
A	ILE202
A	ILE204
A	HOH295
A	HOH456

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 230

Chain	Residue
A	ASN42
A	ASP43
A	ARG74
A	HIS76
A	HOH293
A	HOH445

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 231

Chain	Residue
A	GLN22
A	ASP57
A	HOH473

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 232

Chain	Residue
A	SER185
A	LYS210
A	VAL211
A	SER214
A	HOH469
A	HOH522
A	HOH533

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 233

Chain	Residue
A	HIS0
A	MET1
A	LYS139
A	LYS141
A	SER220

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 234

Chain	Residue
A	GLU128
A	ASN130
A	ASP133
A	EDO224
A	EDO227

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QY0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QY0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QY0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QY0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00336","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22284390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QXS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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