3QVU
Crystal structure of Ancestral variant b9 of SULT 1A1 in complex with PAP and p-nitrophenol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004062 | molecular_function | aryl sulfotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008210 | biological_process | estrogen metabolic process |
| A | 0009308 | biological_process | amine metabolic process |
| A | 0009812 | biological_process | flavonoid metabolic process |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0042420 | biological_process | dopamine catabolic process |
| A | 0047894 | molecular_function | flavonol 3-sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| A | 0051923 | biological_process | sulfation |
| B | 0004062 | molecular_function | aryl sulfotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008210 | biological_process | estrogen metabolic process |
| B | 0009308 | biological_process | amine metabolic process |
| B | 0009812 | biological_process | flavonoid metabolic process |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0042420 | biological_process | dopamine catabolic process |
| B | 0047894 | molecular_function | flavonol 3-sulfotransferase activity |
| B | 0050294 | molecular_function | steroid sulfotransferase activity |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NPO A 296 |
| Chain | Residue |
| A | LYS106 |
| A | HIS108 |
| A | PHE142 |
| A | VAL148 |
| A | HIS149 |
| A | HOH337 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 297 |
| Chain | Residue |
| A | GLN116 |
| A | THR117 |
| A | HOH324 |
| A | LEU31 |
| A | GLN32 |
| A | PHE34 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P A 2001 |
| Chain | Residue |
| A | LYS48 |
| A | SER49 |
| A | GLY50 |
| A | THR51 |
| A | THR52 |
| A | TRP53 |
| A | ARG130 |
| A | SER138 |
| A | TYR193 |
| A | THR227 |
| A | SER228 |
| A | PHE229 |
| A | MET232 |
| A | PHE255 |
| A | MET256 |
| A | ARG257 |
| A | LYS258 |
| A | GLY259 |
| A | HOH305 |
| A | HOH308 |
| A | HOH322 |
| A | HOH333 |
| A | HOH337 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 296 |
| Chain | Residue |
| B | LEU31 |
| B | GLN32 |
| B | PHE34 |
| B | PRO115 |
| B | GLN116 |
| B | THR117 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE A3P B 2001 |
| Chain | Residue |
| B | LYS48 |
| B | SER49 |
| B | GLY50 |
| B | THR51 |
| B | THR52 |
| B | TRP53 |
| B | ARG130 |
| B | SER138 |
| B | TYR193 |
| B | THR227 |
| B | SER228 |
| B | PHE229 |
| B | MET232 |
| B | MET256 |
| B | ARG257 |
| B | LYS258 |
| B | GLY259 |
| B | HOH317 |
| B | HOH324 |
| B | HOH326 |
| B | HOH335 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NPO B 297 |
| Chain | Residue |
| B | PHE81 |
| B | LYS106 |
| B | HIS108 |
| B | PHE142 |
| B | VAL148 |
| B | HIS149 |
| B | MET248 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P0DMM9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12471039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16221673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P17988","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
