3QU3
Crystal structure of IRF-7 DBD apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 135 |
| Chain | Residue |
| A | LEU99 |
| A | HIS100 |
| A | THR102 |
| A | PHE105 |
| A | HOH199 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 135 |
| Chain | Residue |
| B | LEU99 |
| B | THR102 |
| B | PHE105 |
| B | HOH162 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 136 |
| Chain | Residue |
| B | LEU107 |
| B | ARG108 |
| B | HOH278 |
| C | VAL116 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 137 |
| Chain | Residue |
| B | GLY18 |
| B | SER21 |
| B | SER22 |
| B | EDO138 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 138 |
| Chain | Residue |
| B | SER21 |
| B | TRP30 |
| B | EDO137 |
| B | HOH271 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA C 135 |
| Chain | Residue |
| C | LEU99 |
| C | THR102 |
| C | PHE105 |
| C | HOH145 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO C 136 |
| Chain | Residue |
| C | LEU11 |
| C | ASP14 |
| C | TRP68 |
| C | GLY72 |
| C | VAL73 |
| C | ALA80 |
| C | GLU84 |
| C | HOH194 |
| C | HOH252 |
Functional Information from PROSITE/UniProt
| site_id | PS00601 |
| Number of Residues | 33 |
| Details | IRF_1 IRF tryptophan pentad repeat DNA-binding domain signature. WlNeartvFrVPWkHfgrrdldee.DaqIFKaWA |
| Chain | Residue | Details |
| A | TRP30-ALA62 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 351 |
| Details | DNA_BIND: IRF tryptophan pentad repeat => ECO:0000255|PROSITE-ProRule:PRU00840 |
| Chain | Residue | Details |
| A | ARG9-ARG126 | |
| B | ARG9-ARG126 | |
| C | ARG9-ARG126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine; by KAT2A and KAT2B => ECO:0000250|UniProtKB:Q92985 |
| Chain | Residue | Details |
| A | LYS92 | |
| B | LYS92 | |
| C | LYS92 |
