3QPU
PFKFB3 in complex with PPi
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003873 | molecular_function | 6-phosphofructo-2-kinase activity |
| A | 0004331 | molecular_function | fructose-2,6-bisphosphate 2-phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0006003 | biological_process | fructose 2,6-bisphosphate metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043540 | cellular_component | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE POP A 520 |
| Chain | Residue |
| A | GLY71 |
| A | HOH595 |
| A | HOH693 |
| A | EDO750 |
| A | ARG74 |
| A | PHE87 |
| A | ARG98 |
| A | ALA125 |
| A | THR126 |
| A | TYR193 |
| A | HOH553 |
| A | HOH560 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE POP A 550 |
| Chain | Residue |
| A | PRO43 |
| A | ALA44 |
| A | ARG45 |
| A | GLY46 |
| A | LYS47 |
| A | THR48 |
| A | TYR49 |
| A | VAL167 |
| A | LYS168 |
| A | TYR424 |
| A | HOH620 |
| A | HOH622 |
| A | EDO750 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE POP A 600 |
| Chain | Residue |
| A | ARG252 |
| A | HIS253 |
| A | ASN256 |
| A | ASN259 |
| A | GLY265 |
| A | GLU322 |
| A | HIS387 |
| A | GLN388 |
| A | HOH578 |
| A | HOH691 |
| A | HOH734 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SRT A 650 |
| Chain | Residue |
| A | TYR333 |
| A | ARG347 |
| A | LYS351 |
| A | GLN388 |
| A | ARG392 |
| A | HIS441 |
| A | ARG442 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SRT A 700 |
| Chain | Residue |
| A | GLN227 |
| A | ASP228 |
| A | HIS229 |
| A | ARG294 |
| A | GLU375 |
| A | ARG378 |
| A | GLN379 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 750 |
| Chain | Residue |
| A | THR48 |
| A | ASN69 |
| A | ASP124 |
| A | ALA125 |
| A | POP520 |
| A | POP550 |
| A | HOH620 |
| A | HOH707 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 800 |
| Chain | Residue |
| A | PHE87 |
| A | PRO89 |
| A | ARG98 |
| A | CYS192 |
Functional Information from PROSITE/UniProt
| site_id | PS00175 |
| Number of Residues | 10 |
| Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEnEhN |
| Chain | Residue | Details |
| A | LEU250-ASN259 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16316985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17499765","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16316985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25849762","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P07953","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
