3QN9

Crystal structure of a 6-pyruvoyltetrahydropterin synthase homologue from Esherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008616	biological_process	tRNA queuosine(34) biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0070497	molecular_function	6-carboxytetrahydropterin synthase activity
B	0008270	molecular_function	zinc ion binding
B	0008616	biological_process	tRNA queuosine(34) biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0070497	molecular_function	6-carboxytetrahydropterin synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 122

Chain	Residue
A	HIS16
A	HIS31
A	HIS33

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 122

Chain	Residue
B	HIS16
B	HIS31
B	HIS33
B	GLU110

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24816091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QN9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QNA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NTN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24816091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QNA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"24816091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QNA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Increases basicity of active site Cys","evidences":[{"source":"PubMed","id":"24990950","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Site: {"description":"Key residue that determines the differing bacterial enzyme with CTPS activity from the mammalian homolog with PTPS (6-pyruvoyltetrahydropterin synthase) activity","evidences":[{"source":"PubMed","id":"24816091","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---