3QM0

Crystal structure of RTT109-AC-CoA complex

Replaces:  3D35

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010484	molecular_function	histone H3 acetyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG A 800

Chain	Residue
A	CYS94
A	THR96

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG A 801

Chain	Residue
A	GLU109
A	GLU232
A	CYS233

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site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACO A 900

Chain	Residue
A	ARG97
A	VAL98
A	VAL100
A	ARG101
A	PHE192
A	THR193
A	ARG194
A	PRO195
A	ALA196
A	TYR199
A	LYS210
A	HIS211
A	ILE212
A	LEU213
A	LEU218
A	TRP221
A	TRP222
A	VAL85
A	ALA88
A	ASP89
A	THR90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:18707894

Chain	Residue	Details
A	ASP288

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:18568037, ECO:0000269|PubMed:18707894, ECO:0000269|PubMed:18719104, ECO:0000269|PubMed:21256037, ECO:0007744|PDB:2ZFN, ECO:0007744|PDB:3CZ7, ECO:0007744|PDB:3Q33, ECO:0007744|PDB:3Q35, ECO:0007744|PDB:3QM0

Chain	Residue	Details
A	ALA88
A	ARG97
A	HIS211

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18568037, ECO:0007744|PDB:3QM0

Chain	Residue	Details
A	PHE192

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18568037, ECO:0000269|PubMed:21256037, ECO:0007744|PDB:3Q33, ECO:0007744|PDB:3Q35, ECO:0007744|PDB:3QM0

Chain	Residue	Details
A	ALA196

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18707894, ECO:0000269|PubMed:18719104, ECO:0000269|PubMed:21256037, ECO:0007744|PDB:2ZFN, ECO:0007744|PDB:3CZ7, ECO:0007744|PDB:3Q33, ECO:0007744|PDB:3Q35

Chain	Residue	Details
A	TRP221

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:18568037, ECO:0000269|PubMed:18707894, ECO:0000269|PubMed:18719104

Chain	Residue	Details
A	ALY290

---