Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005575 | cellular_component | cellular_component |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005575 | cellular_component | cellular_component |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NDP A 228 |
Chain | Residue |
A | VAL10 |
A | LYS57 |
A | THR58 |
A | VAL77 |
A | SER78 |
A | ARG79 |
A | ASN96 |
A | SER97 |
A | LEU98 |
A | ILE121 |
A | GLY123 |
A | ALA11 |
A | GLY124 |
A | GLU125 |
A | ILE126 |
A | TYR127 |
A | GLN129 |
A | QLZ229 |
A | MG230 |
A | HOH257 |
A | HOH261 |
A | HOH290 |
A | ILE19 |
A | HOH292 |
A | HOH321 |
A | HOH329 |
A | GLY20 |
A | GLY23 |
A | ASN24 |
A | LEU25 |
A | GLY55 |
A | ARG56 |
site_id | AC2 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NDP B 228 |
Chain | Residue |
B | VAL10 |
B | ALA11 |
B | ILE19 |
B | GLY20 |
B | GLY23 |
B | ASN24 |
B | LEU25 |
B | GLY55 |
B | ARG56 |
B | LYS57 |
B | THR58 |
B | VAL77 |
B | SER78 |
B | ARG79 |
B | ASN96 |
B | SER97 |
B | LEU98 |
B | ILE121 |
B | GLY123 |
B | GLY124 |
B | GLU125 |
B | ILE126 |
B | TYR127 |
B | GLN129 |
B | QLZ229 |
B | HOH253 |
B | HOH276 |
B | HOH303 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE QLZ A 229 |
Chain | Residue |
A | ILE9 |
A | VAL10 |
A | ALA11 |
A | LEU25 |
A | GLU32 |
A | MET33 |
A | PHE36 |
A | SER61 |
A | ILE121 |
A | TYR127 |
A | THR140 |
A | NDP228 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE QLZ B 229 |
Chain | Residue |
B | ILE9 |
B | VAL10 |
B | ALA11 |
B | LEU25 |
B | GLU32 |
B | MET33 |
B | PHE36 |
B | SER61 |
B | ILE121 |
B | TYR127 |
B | THR140 |
B | NDP228 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 230 |
Chain | Residue |
A | SER97 |
A | LEU98 |
A | ARG99 |
A | NDP228 |
B | ARG79 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG A 231 |
Chain | Residue |
A | ASP82 |
A | ARG86 |
A | HOH306 |
site_id | AC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG B 230 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGfqgnLPWrlak.EmkyFrevT |
Chain | Residue | Details |
A | GLY18-THR40 | |