3QLS
Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NDP A 193 |
Chain | Residue |
A | VAL10 |
A | LYS57 |
A | THR58 |
A | LEU77 |
A | SER78 |
A | ARG79 |
A | SER94 |
A | ILE112 |
A | GLY113 |
A | GLY114 |
A | ALA115 |
A | ALA11 |
A | GLU116 |
A | ILE117 |
A | TYR118 |
A | GLU120 |
A | GLU174 |
A | 55V194 |
A | HOH211 |
A | HOH234 |
A | HOH242 |
A | HOH247 |
A | ILE19 |
A | HOH272 |
A | HOH331 |
A | HOH344 |
A | HOH346 |
A | HOH356 |
A | GLY23 |
A | LYS24 |
A | MET25 |
A | LYS31 |
A | GLY55 |
A | ARG56 |
site_id | AC2 |
Number of Residues | 36 |
Details | BINDING SITE FOR RESIDUE NDP B 193 |
Chain | Residue |
B | VAL10 |
B | ALA11 |
B | ILE19 |
B | GLY20 |
B | GLY23 |
B | LYS24 |
B | MET25 |
B | GLY55 |
B | ARG56 |
B | LYS57 |
B | THR58 |
B | LEU77 |
B | SER78 |
B | ARG79 |
B | SER94 |
B | SER95 |
B | ILE96 |
B | ILE112 |
B | GLY113 |
B | GLY114 |
B | ALA115 |
B | GLU116 |
B | ILE117 |
B | TYR118 |
B | GLU120 |
B | 55V194 |
B | HOH199 |
B | HOH246 |
B | HOH261 |
B | HOH300 |
B | HOH301 |
B | HOH308 |
B | HOH311 |
B | HOH395 |
B | HOH397 |
B | HOH422 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 55V A 194 |
Chain | Residue |
A | ILE9 |
A | VAL10 |
A | ALA11 |
A | MET25 |
A | GLU32 |
A | PHE36 |
A | SER61 |
A | PRO63 |
A | LEU69 |
A | ILE112 |
A | TYR118 |
A | NDP193 |
A | HOH311 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 55V B 194 |
Chain | Residue |
B | ILE9 |
B | VAL10 |
B | ALA11 |
B | GLU32 |
B | ILE33 |
B | PHE36 |
B | SER61 |
B | ILE112 |
B | TYR118 |
B | NDP193 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GLY A 801 |
Chain | Residue |
A | ASN5 |
A | ARG108 |
A | VAL109 |
A | SER128 |
A | HIS129 |
A | PHE167 |
site_id | AC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GLY B 805 |
Chain | Residue |
B | ILE85 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 902 |
Chain | Residue |
A | HOH223 |
B | LEU102 |
B | ASP105 |
B | HOH200 |
B | HOH297 |
B | HOH310 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL B 903 |
Chain | Residue |
B | HOH236 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 903 |
Chain | Residue |
A | SER94 |
A | SER95 |
A | SER98 |
A | VAL172 |
A | HOH210 |
A | HOH238 |
A | HOH248 |
A | HOH349 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGykgkMPWrlrk.EiryFkdvT |
Chain | Residue | Details |
A | GLY18-THR40 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11520201 |
Chain | Residue | Details |
B | SER78 | |
B | GLY113 | |
A | ALA11 | |
A | GLY18 | |
A | ARG56 | |
A | SER78 | |
A | GLY113 | |
B | ALA11 | |
B | GLY18 | |
B | ARG56 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:11520201 |
Chain | Residue | Details |
A | TYR118 | |
B | GLU32 | |
B | ILE112 | |
B | TYR118 | |
A | GLU32 | |
A | ILE112 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0ABQ4 |
Chain | Residue | Details |
A | ARG72 | |
B | ARG72 |