3QJX
Crystal Structure of E. coli Aminopeptidase N in complex with L-Serine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 880 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | SER900 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 890 |
| Chain | Residue |
| A | HOH1689 |
| A | SER332 |
| A | ASP333 |
| A | GLY335 |
| A | HOH1444 |
| A | HOH1643 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 891 |
| Chain | Residue |
| A | ASP452 |
| A | HOH1288 |
| A | HOH1289 |
| A | HOH1640 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 892 |
| Chain | Residue |
| A | MET260 |
| A | ASN373 |
| A | GLN821 |
| A | HOH1506 |
| A | HOH1530 |
| A | HOH1574 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SER A 900 |
| Chain | Residue |
| A | GLU121 |
| A | MET260 |
| A | ALA262 |
| A | GLU264 |
| A | HIS297 |
| A | GLU298 |
| A | HIS301 |
| A | LYS319 |
| A | GLU320 |
| A | TYR381 |
| A | ZN880 |
| A | GOL976 |
| A | HOH1425 |
| A | HOH1638 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MLI A 950 |
| Chain | Residue |
| A | ARG641 |
| A | GLU642 |
| A | THR645 |
| A | ARG686 |
| A | PHE690 |
| A | ALA722 |
| A | HOH1029 |
| A | HOH1432 |
| A | HOH1573 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 970 |
| Chain | Residue |
| A | LEU532 |
| A | TRP546 |
| A | ASP566 |
| A | ALA567 |
| A | SER570 |
| A | HOH965 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 971 |
| Chain | Residue |
| A | TYR376 |
| A | THR377 |
| A | TYR381 |
| A | GLU382 |
| A | ARG825 |
| A | GOL982 |
| A | HOH1638 |
| A | HOH1705 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 972 |
| Chain | Residue |
| A | TRP71 |
| A | THR72 |
| A | TRP74 |
| A | ARG669 |
| A | VAL670 |
| A | GLU671 |
| A | GOL973 |
| A | HOH1515 |
| A | HOH1794 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 973 |
| Chain | Residue |
| A | LEU61 |
| A | VAL62 |
| A | TRP74 |
| A | ARG669 |
| A | GLU671 |
| A | GOL972 |
| A | HOH1794 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 974 |
| Chain | Residue |
| A | HIS11 |
| A | GLN467 |
| A | ARG468 |
| A | THR469 |
| A | LYS478 |
| A | GLN479 |
| A | PRO480 |
| A | ALA515 |
| A | HOH1115 |
| A | HOH1373 |
| A | HOH1491 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 975 |
| Chain | Residue |
| A | GLU292 |
| A | VAL670 |
| A | HIS672 |
| A | HOH1390 |
| A | HOH1565 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 976 |
| Chain | Residue |
| A | GLY261 |
| A | ARG293 |
| A | HIS297 |
| A | TYR381 |
| A | SER900 |
| A | GOL977 |
| A | HOH1467 |
| A | HOH1705 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 977 |
| Chain | Residue |
| A | LYS274 |
| A | TYR275 |
| A | ARG783 |
| A | GOL976 |
| A | GOL982 |
| A | HOH1776 |
| A | HOH1789 |
| A | ASN259 |
| A | GLY261 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 978 |
| Chain | Residue |
| A | THR284 |
| A | LYS286 |
| A | LEU714 |
| A | LYS748 |
| A | HOH874 |
| A | GOL981 |
| A | HOH1498 |
| A | HOH1758 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 979 |
| Chain | Residue |
| A | VAL162 |
| A | GLN177 |
| A | VAL529 |
| A | GLN549 |
| A | GLN550 |
| A | PHE553 |
| A | GOL983 |
| A | HOH1040 |
| A | HOH1469 |
| A | HOH1575 |
| A | HOH1777 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 981 |
| Chain | Residue |
| A | THR284 |
| A | LYS286 |
| A | ASP287 |
| A | LEU714 |
| A | LYS748 |
| A | HOH874 |
| A | GOL978 |
| A | HOH1498 |
| A | HOH1758 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 982 |
| Chain | Residue |
| A | LYS274 |
| A | TYR275 |
| A | ARG783 |
| A | GOL971 |
| A | GOL977 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 983 |
| Chain | Residue |
| A | GLN177 |
| A | VAL529 |
| A | GLN550 |
| A | GOL979 |
| A | HOH1226 |
| A | HOH1469 |
| A | HOH1777 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW |
| Chain | Residue | Details |
| A | VAL294-TRP303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
