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3QJ3

Structure of digestive procathepsin L2 proteinase from Tenebrio molitor larval midgut

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0008234molecular_functioncysteine-type peptidase activity
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0010952biological_processpositive regulation of peptidase activity
A0051603biological_processproteolysis involved in protein catabolic process
A2001235biological_processpositive regulation of apoptotic signaling pathway
B0004197molecular_functioncysteine-type endopeptidase activity
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0006955biological_processimmune response
B0008234molecular_functioncysteine-type peptidase activity
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0010952biological_processpositive regulation of peptidase activity
B0051603biological_processproteolysis involved in protein catabolic process
B2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT A 401
ChainResidue
AARG94
AASN100
AVAL103
ATYR105
AASP229
AHOH539

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT B 401
ChainResidue
BGLU47
BARG50
AASN201
BGLU43
BASN46

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT B 402
ChainResidue
BCYS169
BSER170
BASP199
BHOH604

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT B 403
ChainResidue
BASN225
BALA228
BASP229
BTYR274
BHOH515
BHOH534
BHOH619
BHOH629

Functional Information from PROSITE/UniProt
site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgdgWGldGYFkI
ChainResidueDetails
ATYR282-ILE301

225946

PDB entries from 2024-10-09

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