Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1 |
| Chain | Residue |
| A | THR54 |
| A | SER69 |
| A | LEU70 |
| A | THR71 |
| A | HOH398 |
| C | ARG90 |
| C | GLN154 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 200 |
| Chain | Residue |
| A | GLY135 |
| A | ASN136 |
| A | ALA175 |
| A | SER176 |
| A | ARG178 |
| C | THR116 |
| A | THR116 |
| A | GLN134 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 201 |
| Chain | Residue |
| A | THR116 |
| A | HOH346 |
| C | THR116 |
| C | GLN134 |
| C | GLY135 |
| C | ASN136 |
| C | ALA175 |
| C | SER176 |
| C | ARG178 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | ARG26 |
| A | THR121 |
| A | ARG130 |
| A | HOH352 |
| C | ARG130 |
| C | HOH318 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | PRO174 |
| A | ALA175 |
| A | SER176 |
| A | HOH399 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | ASN13 |
| A | THR44 |
| A | ARG46 |
| A | HOH396 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 205 |
| Chain | Residue |
| A | ASN63 |
| A | ASN63 |
| A | ARG65 |
| A | ARG65 |
| A | PRO187 |
| A | PRO187 |
| A | HOH355 |
| A | HOH355 |
| A | HOH487 |
| A | HOH487 |
| A | HOH509 |
| A | HOH509 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TFA A 206 |
| Chain | Residue |
| A | ASN14 |
| A | ARG46 |
| A | GLY49 |
| A | HOH401 |
| A | HOH434 |
| C | ASN167 |
| C | ASN169 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TFA A 207 |
| Chain | Residue |
| A | ARG79 |
| A | PHE86 |
| A | HOH400 |
| A | HOH410 |
| A | HOH418 |
| A | HOH499 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TFA A 208 |
| Chain | Residue |
| A | ARG26 |
| A | GLY127 |
| A | ALA128 |
| A | ARG130 |
| A | HOH301 |
| A | HOH397 |
| A | HOH496 |
| C | ARG79 |
| C | THR88 |
| C | ARG90 |
| C | HOH373 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 200 |
| Chain | Residue |
| A | ASN119 |
| C | ASN123 |
| C | HOH510 |
| D | ALA2 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 201 |
| Chain | Residue |
| C | ARG65 |
| C | ARG130 |
| C | HOH381 |
| C | HOH474 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 202 |
| Chain | Residue |
| C | ASN136 |
| C | ALA137 |
| C | CYS138 |
| C | PRO174 |
| C | ALA175 |
| C | ARG178 |
| C | HOH319 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 203 |
| Chain | Residue |
| C | HIS37 |
| C | ARG58 |
| C | PHE60 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 204 |
| Chain | Residue |
| C | HOH520 |
| D | PRO4 |
| C | ASN13 |
| C | ASN14 |
| C | HIS37 |
| C | GLU126 |
| C | ARG141 |
| C | HOH334 |
| C | HOH426 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TFA C 205 |
| Chain | Residue |
| C | SER84 |
| C | GLU94 |
| C | LYS118 |
| C | ARG184 |
| C | HOH312 |
| C | HOH335 |
| C | HOH400 |
| C | HOH450 |
| site_id | BC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN B OF AC-ALAALAPRO-ALANAL PEPTIDE |
| Chain | Residue |
| A | HIS37 |
| A | TYR124 |
| A | GLU126 |
| A | GLY140 |
| A | ARG141 |
| A | GLY142 |
| A | ASP143 |
| A | SER144 |
| A | SER160 |
| A | GLY161 |
| A | GLY162 |
| A | ASN163 |
| B | HOH108 |
| C | HOH320 |
| site_id | BC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN D OF AC-ALAALAPRO-ALANAL PEPTIDE |
| Chain | Residue |
| C | HIS37 |
| C | TYR124 |
| C | GLU126 |
| C | GLY140 |
| C | ARG141 |
| C | GLY142 |
| C | ASP143 |
| C | SER144 |
| C | SER160 |
| C | GLY161 |
| C | GLY162 |
| C | ASN163 |
| C | VAL164 |
| C | EDO200 |
| C | SO4204 |
| C | HOH366 |
| C | HOH426 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
| Chain | Residue | Details |
| A | VAL33-CYS38 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
| Chain | Residue | Details |
| A | CYS138-ILE149 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS37 | |
| A | ASP64 | |
| A | SER144 | |
| C | HIS37 | |
| C | ASP64 | |
| C | SER144 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| A | HIS37 | proton acceptor, proton donor |
| A | ASP64 | electrostatic stabiliser |
| A | GLY142 | electrostatic stabiliser |
| A | SER144 | electrostatic stabiliser |
| A | SER160 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| C | HIS37 | proton acceptor, proton donor |
| C | ASP64 | electrostatic stabiliser |
| C | GLY142 | electrostatic stabiliser |
| C | SER144 | electrostatic stabiliser |
| C | SER160 | electrostatic stabiliser |
