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3QGH

Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE 63F A 601
ChainResidue
AVAL179
ACYS289
ASER368
AILE413
AMET414
APHE415
AILE447
ATYR448
ATYR452
AILE454
AILE462
ATYR191
ALEU547
APHE551
ATYR555
AHOH971
AGLY192
APHE193
ATYR195
ASER196
APRO197
AARG200
ASER288

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 A 651
ChainResidue
AARG32
AHIS33
AGLU237
AGLN241
ALYS254
AHOH907
AHOH938

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 652
ChainResidue
AARG48
ALYS51
AARG222
ACYS223
AHOH897
AHOH1009

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 A 653
ChainResidue
AARG505
AVAL530
AARG531
ATHR532

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 A 654
ChainResidue
AGLN19
ATYR38
ASER39
ATHR40
ATHR41
ASER44
AARG154
AHOH1015

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 655
ChainResidue
AARG48
AVAL52
AARG158
ALEU159
AHOH886
AHOH1023

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues118
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P26663","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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